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HEMS-HESE 的取代度对相应水凝胶中包埋药物模型释放的影响。

Influence of degree of substitution of HES-HEMA on the release of incorporated drug models from corresponding hydrogels.

机构信息

Technical University of Braunschweig, Institute of Biochemistry and Biotechnology, Braunschweig, Germany.

出版信息

Eur J Pharm Biopharm. 2009 Nov;73(3):351-6. doi: 10.1016/j.ejpb.2009.08.003. Epub 2009 Aug 14.

DOI:10.1016/j.ejpb.2009.08.003
PMID:19683570
Abstract

Hydrogel microparticles were produced by a radical polymerization of hydroxyethyl methacrylate-hydroxyethyl starch (HES-HEMA) in an all aqueous two-phase system (ATPS). The microspheres show a monomodal size distribution and have the ability to entrap high amounts of water. The release of proteins or other testing substances from the HES-HEMA hydrogels can be controlled by the choice of the network density of the hydrogel by varying the degree of substitution (DS), the size of the entrapped substance, and by conditions enhancing the degradation of the hydrogel network.

摘要

水凝胶微球是通过在全水两相体系（ATPS）中羟乙基甲基丙烯酸酯-羟乙基淀粉（HES-HEMA）的自由基聚合制备的。微球呈现单峰尺寸分布，并且具有能够包埋大量水的能力。通过改变取代度（DS）、包埋物质的大小以及通过增强水凝胶网络降解的条件来选择水凝胶的网络密度，可以控制蛋白质或其他测试物质从 HES-HEMA 水凝胶中的释放。

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