Cohen Alex S, Davis Thompson E
Department of Psychology, Louisiana State University, Baton Rouge, LA 70808, USA.
Compr Psychiatry. 2009 Sep-Oct;50(5):408-14. doi: 10.1016/j.comppsych.2008.11.002. Epub 2009 Jan 16.
It is well documented that patients with schizophrenia have impoverished quality of life (QOL). Efforts to determine the underpinnings of this impoverishment have implicated negative symptoms more than positive or disorganized symptoms. However, only a minority of individuals with the liability to schizophrenia will ever show manifest illness, and it is presently unclear the degree to which QOL is affected in individuals with subclinical symptoms of the disorder (ie, schizotypy). The present study examined the relative contributions of negative, positive, and disorganized schizotypy symptoms to QOL.
Measures of schizotypal symptoms and subjective and objective QOL were obtained from a sample of 1395 adults.
Measures of schizotypal symptoms significantly corresponded to all measures of QOL, although the magnitude of correlations were significantly larger for subjective than objective measures. The negative symptom dimension explained a substantial portion of unique variance in the social domains of QOL above and beyond that accounted for by the other schizotypy dimensions.
These findings highlight the deleterious impact of schizotypal symptoms, particularly negative symptoms. Further research clarifying the mechanism underlying this relationship is called for.
有充分证据表明，精神分裂症患者的生活质量（QOL）较差。为确定这种较差状况的根源所做的努力表明，负性症状比阳性症状或紊乱症状的影响更大。然而，只有少数有精神分裂症倾向的个体最终会表现出明显的疾病症状，目前尚不清楚该疾病的亚临床症状（即分裂型人格特质）个体的生活质量受影响的程度。本研究考察了负性、阳性和紊乱型分裂型人格特质症状对生活质量的相对影响。
从1395名成年人样本中获取分裂型人格特质症状以及主观和客观生活质量的测量数据。
分裂型人格特质症状的测量结果与所有生活质量测量指标均显著相关，尽管主观测量指标的相关程度显著高于客观测量指标。负性症状维度解释了生活质量社会领域中超出其他分裂型人格特质维度所解释的独特方差的很大一部分。
这些发现凸显了分裂型人格特质症状，尤其是负性症状的有害影响。需要进一步研究以阐明这种关系背后的机制。
