Andres E, Serraj K, Mecili M, Ciobanu E, Vogel T, Weitten T
Service de médecine interne, diabète et maladies métaboliques, clinique médicale B, hôpital Civil, hôpitaux universitaires de Strasbourg, 67091 Strasbourg cedex, France.
Ann Endocrinol (Paris). 2009 Dec;70(6):455-61. doi: 10.1016/j.ando.2009.07.001. Epub 2009 Aug 15.
The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment.
PubMed was systematically searched for English and French articles published from January 1990 to January 2007.
Prospective randomized studies (n = 3), a systematic review by the Cochrane group (n = 1) and prospective studies in well-determined population (n = 5) provide evidence that oral cyanocobalamin therapy may adequately treat cobalamin deficiency in elderly patients. However, the current literature may not suggest a strategy in terms of the form (hydroxy- or cyanocobalamin), frequency and duration of the treatment.
This present review confirms the previously reported efficacy of oral cyanocobalamin treatment in elderly patients.
本综述的目的是评估口服钴胺素（维生素B12）治疗的有效性。
系统检索PubMed中1990年1月至2007年1月发表的英文和法文文章。
前瞻性随机研究（n = 3）、Cochrane协作网的系统评价（n = 1）以及在特定人群中的前瞻性研究（n = 5）提供了证据，表明口服氰钴胺素疗法可充分治疗老年患者的钴胺素缺乏症。然而，目前的文献可能未就治疗的形式（羟钴胺素或氰钴胺素）、频率和持续时间提出策略。
本综述证实了先前报道的口服氰钴胺素治疗老年患者的疗效。
