Andrès Emmanuel, Vogel Thomas, Federici Laure, Zimmer Jacques, Kaltenbach Georges
Department of Internal Medicine, Diabetes and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
Drugs Aging. 2008;25(11):927-32. doi: 10.2165/0002512-200825110-00003.
The objective of this review is to evaluate the usefulness of oral cobalamin (vitamin B12) treatment in elderly patients. PubMed was systematically searched for English and French articles published from January 1990 to January 2007. Prospective randomized studies (n=3), a systematic review by the Cochrane group (n=1) and prospective studies in a well defined population (n=5) provide evidence that oral cobalamin therapy may adequately treat cobalamin deficiency in elderly patients. However, the current literature does not suggest a strategy in terms of the form (hydroxy- or cyanocobalamin), frequency and duration of the treatment. This review confirms the previously reported efficacy of oral cobalamin treatment in elderly patients. Oral cobalamin treatment avoids the discomfort, inconvenience and cost of monthly injections.
本综述的目的是评估口服钴胺素（维生素B12）治疗老年患者的有效性。对PubMed进行了系统检索，以查找1990年1月至2007年1月发表的英文和法文文章。前瞻性随机研究（n = 3）、Cochrane小组的系统评价（n = 1）以及在明确界定人群中的前瞻性研究（n = 5）提供了证据，表明口服钴胺素疗法可能足以治疗老年患者的钴胺素缺乏症。然而，目前的文献并未就治疗的形式（羟钴胺或氰钴胺）、频率和持续时间提出策略。本综述证实了先前报道的口服钴胺素治疗老年患者的疗效。口服钴胺素治疗避免了每月注射带来的不适、不便和费用。
