精神分裂症患者前海马体和眶额皮质的脑结构异常与认知缺陷相关。
Anterior hippocampal and orbitofrontal cortical structural brain abnormalities in association with cognitive deficits in schizophrenia.
作者信息
Schobel Scott A, Kelly Meredith A, Corcoran Cheryl M, Van Heertum Kristin, Seckinger Regine, Goetz Ray, Harkavy-Friedman Jill, Malaspina Dolores
机构信息
Center for Prevention and Evaluation, New York State Psychiatric Institute, USA.
出版信息
Schizophr Res. 2009 Oct;114(1-3):110-8. doi: 10.1016/j.schres.2009.07.016. Epub 2009 Aug 15.
OBJECTIVE
Numerous studies have implicated the hippocampus and prefrontal cortex in schizophrenia. However, precisely which subregions of the hippocampus and prefrontal cortex are abnormal remain unknown. Our study goal was to investigate the structure of the anterior hippocampus, posterior hippocampus, dorsolateral prefrontal cortex (DLPFC), and orbitofrontal cortex (OFC) simultaneously in thirty-eight patients with schizophrenia and twenty-nine controls to determine which of these subregions are abnormal in schizophrenia. As an exploratory study goal, we investigated the relation of neurocognition to brain structure in schizophrenia patients.
METHOD
We generated detailed structural magnetic resonance imaging data and compared hippocampal and prefrontal subregional structural brain volumes between schizophrenia and control groups. We obtained a neurocognitive test battery in schizophrenia patients and studied the association of abnormal brain structures to neurocognition.
RESULTS
Structural brain abnormalities were pinpointed to the left anterior hippocampus and left OFC in schizophrenia patients, which were both significantly reduced in volume. The DLPFC and posterior hippocampus, though numerically decreased in volume, were not significantly decreased. Anterior hippocampal volumes were more strongly associated with OFC volumes in schizophrenia patients compared to controls. By contrast, DLPFC volume was unrelated to anterior or posterior hippocampal volume. Both the anterior hippocampus and OFC were independently related to cognitive abnormalities common in schizophrenia, including indices of verbal, language, and executive functions. The DLPFC and posterior hippocampal volumes were unrelated to cognitive measures.
CONCLUSIONS
These findings highlight related abnormalities of the anterior hippocampus and OFC in schizophrenia, which may shed light on the pathophysiology of the disorder.
目的
众多研究表明海马体和前额叶皮质与精神分裂症有关。然而，海马体和前额叶皮质中究竟哪些亚区域存在异常仍不清楚。我们的研究目标是同时对38例精神分裂症患者和29名对照者的前海马体、后海马体、背外侧前额叶皮质（DLPFC）和眶额皮质（OFC）的结构进行研究，以确定这些亚区域中哪些在精神分裂症中存在异常。作为一项探索性研究目标，我们研究了精神分裂症患者神经认知与脑结构之间的关系。
方法
我们生成了详细的结构磁共振成像数据，并比较了精神分裂症患者和对照组之间海马体和前额叶亚区域的脑结构体积。我们对精神分裂症患者进行了一系列神经认知测试，并研究了异常脑结构与神经认知之间的关联。
结果
精神分裂症患者的脑结构异常定位于左侧前海马体和左侧OFC，两者体积均显著减小。DLPFC和后海马体虽然体积在数值上有所下降，但没有显著减小。与对照组相比，精神分裂症患者前海马体体积与OFC体积的相关性更强。相比之下，DLPFC体积与前海马体或后海马体体积无关。前海马体和OFC均与精神分裂症常见的认知异常独立相关，包括言语、语言和执行功能指标。DLPFC和后海马体体积与认知测量无关。
结论
这些发现突出了精神分裂症中前海马体和OFC的相关异常，这可能有助于揭示该疾病的病理生理学机制。
Zotero 插件