Eli Lilly and Company, Lilly Research Laboratories, BioTechnology Discovery Research, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Curr Opin Pharmacol. 2009 Dec;9(6):805-10. doi: 10.1016/j.coph.2009.07.001. Epub 2009 Aug 14.
Although the first fibroblast growth factor (FGF) was discovered as a mitogen on 3T3 fibroblasts [Gospodarowicz D: Localization of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature 1974, 249:123-127], this name is functionally misleading. This group of secreted proteins consisting now of 22 members was composed based on common structural characteristics rather than on functional similarity. Thus, only a few members of the human FGF family promote growth and strictly act on fibroblasts. While the research in the last century firmly established FGFs as key players in development, morphogenesis, angiogenesis, hematopoiesis, and survival, this decade provided clues on FGF roles in metabolism. In particular, 'hormone-like' FGF19, FGF21, and FGF23, were shown to be involved in glucose, lipid, bile acid, phosphate, and vitamin D metabolism but the mechanisms underlying their functions as metabolic regulators are still being defined.
虽然第一个成纤维细胞生长因子（FGF）是作为一种有丝分裂原在 3T3 成纤维细胞上发现的[Gospodarowicz D: 成纤维细胞生长因子的定位及其单独和与氢化可的松对 3T3 细胞生长的影响。自然 1974, 249:123-127]，但这个名称在功能上是具有误导性的。这组分泌蛋白现在由 22 个成员组成，是基于共同的结构特征而不是功能相似性而组成的。因此，人类 FGF 家族中只有少数成员促进生长并严格作用于成纤维细胞。虽然上个世纪的研究已经确定 FGF 是发育、形态发生、血管生成、造血和存活的关键因素，但这十年为 FGF 在代谢中的作用提供了线索。特别是，“类激素”FGF19、FGF21 和 FGF23 被证明参与葡萄糖、脂质、胆汁酸、磷酸盐和维生素 D 代谢，但它们作为代谢调节剂的功能的机制仍在确定中。
