Department of Neonatology, The Second Affiliated Hospital of Wenzhou Medical University and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Key Laboratory of Perinatal Medicine of Wenzhou, Wenzhou, Zhejiang, China.
Mol Neurobiol. 2023 Dec;60(12):7021-7031. doi: 10.1007/s12035-023-03490-w. Epub 2023 Aug 1.
Brown adipose tissue (BAT) is a special type of fat tissue in mammals and is also a key endocrine organ in the human body. Batokine, the endocrine effector of BAT, plays a neuroprotective role and improves the prognosis by exerting anti-apoptotic and anti-inflammatory effects, as well as by improving vascular endothelial function and other mechanisms in nerve injury diseases. The present article briefly reviewed several types of batokines related to central nervous system (CNS) diseases. Following this, the potential therapeutic value and future research direction of batokines for CNS diseases were chiefly discussed from the aspects of protective mechanism and signaling pathway.
棕色脂肪组织（BAT）是哺乳动物中一种特殊的脂肪组织，也是人体中的一个关键内分泌器官。BAT 的内分泌效应物 Batokine 通过发挥抗细胞凋亡和抗炎作用，以及改善血管内皮功能等机制，在神经损伤性疾病中发挥神经保护作用，改善预后。本文简要综述了几种与中枢神经系统（CNS）疾病相关的 Batokine。随后，主要从保护机制和信号通路两个方面讨论了 Batokine 治疗 CNS 疾病的潜在治疗价值和未来研究方向。
