Pilloni L, Bianco P, Manieli C, Senes G, Coni P, Atzori L, Aste N, Faa G
Eur J Histochem. 2009 Apr-Jun;53(2):e14. doi: 10.4081/ejh.2009.e14.
Basal cell carcinoma (BCC) is a very common malignant skin tumor that rarely metastatizes, but is often locally aggressive. Several factors, like large size (more than 3 cm), exposure to ultraviolet rays, histological variants, level of infiltration and perineural or perivascular invasion, are associated with a more aggressive clinical course. These morphological features seem to be more determinant in mideface localized BCC, which frequently show a significantly higher recurrence rate. An immunohistochemical profile, characterized by reactivity of tumor cells for p53, Ki67 and alpha-SMA has been associated with a more aggressive behaviour in large BCCs. The aim of this study was to verify if also little (<3 cm) basal cell carcinomas can express immunohistochemical markers typical for an aggressive behaviour.
基底细胞癌（BCC）是一种非常常见的恶性皮肤肿瘤，很少发生转移，但通常具有局部侵袭性。几个因素，如肿瘤较大（超过3厘米）、暴露于紫外线、组织学变体、浸润程度以及神经周围或血管周围侵犯，都与更具侵袭性的临床病程相关。这些形态学特征在面部中部局限性基底细胞癌中似乎更具决定性，这类肿瘤通常复发率显著更高。一种免疫组化特征，表现为肿瘤细胞对p53、Ki67和α-SMA呈阳性反应，与大型基底细胞癌更具侵袭性的行为相关。本研究的目的是验证小型（<3厘米）基底细胞癌是否也能表达侵袭性行为典型的免疫组化标志物。
