Reibnegger G, Fuchs D, Goedert J J, Hausen A, Krämer A, Werner E R, Werner-Felmayer G, Dierich M P, Wachter H
Institut für Medizinische Chemie und Biochemie, Universität Innsbruck, Osterreich.
Klin Wochenschr. 1990 Jan 4;68(1):43-8. doi: 10.1007/BF01648890.
We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression.
我们研究了尿新蝶呤浓度和T细胞亚群数据及其比值在区分抗HIV-1血清阴性者、血清阳性者和艾滋病患者方面的能力。通过绘制受试者工作特征曲线，发现新蝶呤水平具有最佳的区分能力。在从单一变量得出的比值中，每CD4+细胞计数的新蝶呤和每CD4+/CD8+细胞比值的新蝶呤优于CD4+/CD8+细胞比值。使用广义似然比方法以及线性判别分析进行了多变量分析。新蝶呤浓度和CD4+ T细胞计数的组合非常适合区分HIV-1感染的各个阶段，因此，我们建议使用不止一种检测方法来评估疾病进展。
