Albert A
Clin Chem. 1982 May;28(5):1113-9.
The clinical relevance of likelihood ratios (L-values) for revising the physician's diagnostic probabilities has been recognized. However, the calculation of L-values, particularly in the case of quantitative or mixed quantitative-binary test results, raises problems that have not yet been addressed. Based on a very general assumption that yields a simple functional form for the likelihood ratio, a method is developed that allows such calculations regardless of the nature and the number of clinical laboratory tests to be interpreted simultaneously. Hence the notion of predictive value (posterior probability) is extended from binary or dichotomized tests to quantitative tests, and from univariate to multivariate clinical laboratory results. The simplicity and flexibility of this approach eliminates difficulties in computation arising from the addition of new data to an existing data base. It is hoped that this method will now allow L-values to be reported along with the original test results in daily laboratory practice.
似然比（L值）在修正医生诊断概率方面的临床相关性已得到认可。然而，L值的计算，尤其是在定量或定量 - 二元混合检测结果的情况下，会引发一些尚未解决的问题。基于一个能得出似然比简单函数形式的非常普遍的假设，开发了一种方法，该方法允许进行此类计算，而不管同时要解释的临床实验室检测的性质和数量如何。因此，预测值（后验概率）的概念从二元或二分检测扩展到定量检测，从单变量临床实验室结果扩展到多变量临床实验室结果。这种方法的简单性和灵活性消除了因向现有数据库添加新数据而产生的计算困难。希望这种方法现在能使L值在日常实验室实践中与原始检测结果一起报告。
