Liu Wenfeng, Jiang Zhiyong, Chen Jijun, Zhang Xuemei, Ma Yunbao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
Zhongguo Zhong Yao Za Zhi. 2009 May;34(9):1101-3.
To study the chemical constituents of Piper longum.
The whole plant of air-dried P. longum. was extracted with 95% EtOH. The EtOH extract was suspended in H2O and extracted with petroleum ether, CHC13 and n-BuOH, successively. The compounds were isolated and purified by column chromatography from the CHCl3 fraction, and identified based on spectral analyses (MS,1H-NMR, 13C-NMR).
Threeteen compounds were isolated from P. longum, and were characterized as 1-(3',4'-methylenedioxyphenyl)-1E-tetradecene (1), 3-(3', 4'-methylenedioxophenyl)-propenal (2), piperoic acid (3), 3',4'-di-hydroxy-biabola-1,10-diene (4), eudesm-4(15)-ene-1beta, 6alpha-diol (5), 7-epi- eudesm-4( 15)-ene-1beta, 6beta-diol (6), guineesine (7), piperine (8), pipericide (9), 2E, 4E-dienamide (10), (2E, 4E, 8E) -N-isobutylhenicosa-2,4,8-trienamide (11), piperlonguminine (12), methyl piperate (13),
Compounds 1-6 were obtained from P. longum for the first time.
研究荜茇的化学成分。
将风干的荜茇全草用95%乙醇提取。乙醇提取物悬浮于水中，依次用石油醚、三氯甲烷和正丁醇萃取。从三氯甲烷部分通过柱色谱分离纯化化合物，并基于光谱分析（质谱、氢核磁共振、碳核磁共振）进行鉴定。
从荜茇中分离出13种化合物，分别鉴定为1-(3',4'-亚甲二氧基苯基)-1E-十四碳烯(1)、3-(3',4'-亚甲二氧基苯基)-丙烯醛(2)、胡椒酸(3)、3',4'-二羟基-毕拨-1,10-二烯(4)、桉叶-4(15)-烯-1β,6α-二醇(5)、7-表-桉叶-4(15)-烯-1β,6β-二醇(6)、几内亚宁(7)、胡椒碱(8)、胡椒酰胺(9)、2E,4E-二烯酰胺(10)、(2E,4E,8E)-N-异丁基二十一碳-2,4,8-三烯酰胺(11)、荜茇明宁碱(12)、胡椒酸甲酯(13)。
化合物1 - 6首次从荜茇中获得。
