Liu Wenfeng, Jiang Zhiyong, Chen Jijun, Zhang Xuemei, Ma Yunbao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.
Zhongguo Zhong Yao Za Zhi. 2009 Nov;34(22):2891-4.
To study the chemical constituents of Piper longum.
The whole plant of air-dried P. longum was extracted with 95% EtOH. The EtOH extract was suspended in H2O and extracted with petroleum ether, CHCl3 and n-BuOH, successively. The compounds were isolated and purified by column chromatography from the CHCl3 fraction, and identified based on spectral analyses (MS, 1H-NMR, 13C-NMR).
Eleven compounds were isolated from P. longum, and were characterized as coumaperine (1), N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine (2), piperolactam A (3), 1-[1-oxo-5 (3,4-methylenedioxyphenyl) -2E,4E-pentadienyl] -pirrolidine (4), 1-[1-oxo-5 (3,4-methylenedioxyphenyl) -2E-pentenyl] -pirrolidine (5), 1-[1-oxo-9 (3,4-methylene dioxyphenyl)-2E, 8E-nonadienyl] -pyrrolidine (6), (R)-(-) -turmerone (7), octahydro-4-hydroy-3alpha-methyl-7-methylene-alpha-(1-methylethyl)-1H-indene-1-methanol (8), (+) -aphanamol I (9), bisdemethoxycurcumin (10), demethoxycurcumin (11).
Compounds 1-11 were obtained from P. longum for the first time.
