青少年男性和女性饮食失调的遗传风险因素。
Genetic risk factors for disordered eating in adolescent males and females.
作者信息
Baker Jessica H, Maes Hermine H, Lissner Lauren, Aggen Steven H, Lichtenstein Paul, Kendler Kenneth S
机构信息
Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284, USA.
出版信息
J Abnorm Psychol. 2009 Aug;118(3):576-86. doi: 10.1037/a0016314.
Abstract
The etiologic role of genetic and environmental factors on disordered eating was examined in a sample of 15- to 17-year-old female-female, male-male, and opposite-sex twin pairs. Also assessed was whether a single factor is underlying 3 facets (body dissatisfaction, drive for thinness, bulimia) of disordered eating, including the possible importance of sex differences. Univariate model-fitting analyses indicated that genetic factors are more important for girls and environment more important for boys for body dissatisfaction and drive for thinness. A multivariate common factor analysis indicated that a single factor accounted for the association among these 3 facets of disordered eating in both sexes. However, only 50% of the genetic risk for this factor is shared between the sexes.
摘要
在一组15至17岁的女性同性、男性同性和异性双胞胎样本中，研究了遗传和环境因素在饮食失调中的病因作用。同时还评估了是否存在一个单一因素是饮食失调的三个方面（身体不满、追求瘦身、贪食症）的基础，包括性别差异的可能重要性。单变量模型拟合分析表明，对于身体不满和追求瘦身，遗传因素对女孩更重要，环境因素对男孩更重要。多变量共同因素分析表明，一个单一因素解释了男女饮食失调这三个方面之间的关联。然而，该因素的遗传风险在两性之间只有50%是共同的。
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2
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3
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9
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