青春期前去除雌激素对雌性大鼠暴饮暴食风险的干扰作用。
The Disruptive Effects of Estrogen Removal before Puberty on Risk for Binge Eating in Female Rats.
作者信息
Klump Kelly L, Sinclair Elaine B, Hildebrandt Britny A, Kashy Deborah A, O'Connor Shannon, Mikhail Megan E, Culbert Kristen M, Johnson Alexander, Sisk Cheryl L
机构信息
Department of Psychology, Michigan State University, East Lansing, MI 48824-1116.
Neuroscience Program, Michigan State University, East Lansing, MI 48824-1116.
出版信息
Clin Psychol Sci. 2020 Sep 1;8(5):839-856. doi: 10.1177/2167702620921343. Epub 2020 Jul 2.
Recent research suggests that estrogen is protective against binge eating in adult females, and that pubertal estrogen may be critical for these effects. Nonetheless, to date, no study has examined the role of pubertal estrogen in adult binge eating phenotypes in females, potentially due to difficulties experimentally manipulating estrogen in humans to examine causal effects. We used a novel animal model to examine whether estrogen removal prior to puberty (via pre-pubertal ovariectomy (P-OVX)) increases rates of binge eating prone (BEP) phenotypes in adulthood in females. A total of 77 P-OVX and 79 intact rats were followed from pre-puberty into adulthood and phenotyped for BEP status in adulthood. Results showed significantly increased rates (~2-8x higher) of adult BEP phenotypes in P-OVX as compared to intact rats. Findings confirm that estrogen removal substantially increases later risk for binge eating in females, potentially by disrupting typical adolescent brain development.
近期研究表明，雌激素对成年女性的暴饮暴食具有保护作用，且青春期雌激素可能对这些作用至关重要。然而，迄今为止，尚无研究探讨青春期雌激素在成年女性暴饮暴食表型中的作用，这可能是由于在人体中通过实验操纵雌激素来研究因果效应存在困难。我们使用了一种新型动物模型来研究青春期前去除雌激素（通过青春期前卵巢切除术（P-OVX））是否会增加成年雌性大鼠暴饮暴食倾向（BEP）表型的发生率。从青春期前到成年期，共对77只接受P-OVX手术的大鼠和79只完整大鼠进行了跟踪，并对成年期的BEP状态进行了表型分析。结果显示，与完整大鼠相比，接受P-OVX手术的大鼠成年期BEP表型的发生率显著增加（约高2至8倍）。研究结果证实，去除雌激素会大幅增加雌性大鼠日后暴饮暴食的风险，这可能是通过扰乱典型的青少年大脑发育来实现的。
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