Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki-city, Kanagawa-prefecture, Japan.
Annu Rev Med. 2010;61:271-86. doi: 10.1146/annurev.med.041908.191750.
Recently, an increasing number of cases of stress cardiomyopathy, mainly occurring in elderly women, have been documented in many parts of the world. In Japan, this disease is known as takotsubo cardiomyopathy (named after the fishing pot used for trapping octopus). Symptoms of this condition are akin to those of acute myocardial infarction, but no obstructive lesions are found in the coronary arteries, and left ventricular apical ballooning is present. Stress cardiomyopathy is now a well-recognized cause of acute heart failure, lethal ventricular arrhythmias, and ventricular rupture. Although the precise mechanism of onset of this condition is still controversial, two major pathogenic mechanisms have been proposed: catecholamine cardiotoxicity and neurogenic stunned myocardium. We summarize the findings of studies conducted to date on stress cardiomyopathy-from bench to bedside and bedside to bench.
最近，在世界许多地方都记录到越来越多的应激性心肌病病例，主要发生在老年妇女中。在日本，这种疾病被称为章鱼壶心肌病（以用于捕捉章鱼的捕鱼壶命名）。这种疾病的症状类似于急性心肌梗死，但冠状动脉中没有发现阻塞性病变，并且左心室心尖部呈气球样扩张。应激性心肌病现在是急性心力衰竭、致命性室性心律失常和心室破裂的一个公认原因。尽管这种疾病的确切发病机制仍存在争议，但已经提出了两种主要的发病机制：儿茶酚胺心脏毒性和神经源性心肌顿抑。我们总结了迄今为止对应激性心肌病的研究结果——从实验室到临床，再从临床到实验室。
