Gelperin Alan, Ghatpande Ambarish
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.
Ann N Y Acad Sci. 2009 Jul;1170:277-85. doi: 10.1111/j.1749-6632.2009.04110.x.
The neural basis of olfactory information processing and olfactory percept formation is a topic of intense investigation as new genetic, optical, and psychophysical tools are brought to bear to identify the sites and interaction modes of cortical areas involved in the central processing of olfactory information. New methods for recording cellular interactions and network events in the awake, behaving brain during olfactory processing and odor-based decision making have shown remarkable new properties of neuromodulation and synaptic interactions distinct from those observed in anesthetized brains. Psychophysical, imaging, and computational studies point to the orbitofrontal cortex as the likely locus of odor percept formation in mammals, but further work is needed to identify a causal link between perceptual and neural events in this area.
随着新的遗传学、光学和心理物理学工具被用于识别参与嗅觉信息中枢处理的皮质区域的位点和相互作用模式，嗅觉信息处理和嗅觉感知形成的神经基础成为了一个深入研究的课题。在嗅觉处理和基于气味的决策过程中，用于记录清醒、行为活跃大脑中细胞相互作用和网络事件的新方法，已经显示出神经调节和突触相互作用的显著新特性，这些特性与在麻醉大脑中观察到的不同。心理物理学、成像和计算研究表明，眶额皮质可能是哺乳动物气味感知形成的位点，但需要进一步的研究来确定该区域感知事件和神经事件之间的因果联系。
