Neural basis of olfactory perception.

The neural basis of olfactory information processing and olfactory percept formation is a topic of intense investigation as new genetic, optical, and psychophysical tools are brought to bear to identify the sites and interaction modes of cortical areas involved in the central processing of olfactory information. New methods for recording cellular interactions and network events in the awake, behaving brain during olfactory processing and odor-based decision making have shown remarkable new properties of neuromodulation and synaptic interactions distinct from those observed in anesthetized brains. Psychophysical, imaging, and computational studies point to the orbitofrontal cortex as the likely locus of odor percept formation in mammals, but further work is needed to identify a causal link between perceptual and neural events in this area.