Shinbrot Troy, Chun Young, Caicedo-Carvajal Carlos, Foty Ramsey
Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08854, USA.
Biophys J. 2009 Aug 19;97(4):958-67. doi: 10.1016/j.bpj.2009.05.020.
We describe a model that simulates spherical cells of different types that can migrate and interact either attractively or repulsively. We find that both expected morphologies and previously unreported patterns spontaneously self-assemble. Among the newly discovered patterns are a segmented state of alternating discs, and a "shish-kebab" state, in which one cell type forms a ring around a second type. We show that these unique states result from cellular attraction that increases with distance (e.g., as membranes stretch viscoelastically), and would not be seen in traditional, e.g., molecular, potentials that diminish with distance. Most of the states found computationally have been observed in vitro, and it remains to be established what role these self-assembled states may play in in vivo morphogenesis.
我们描述了一个模型，该模型模拟了不同类型的球形细胞，这些细胞可以进行迁移，并以吸引或排斥的方式相互作用。我们发现，预期的形态以及以前未报道过的模式会自发地自我组装。新发现的模式包括交替圆盘的分段状态和“烤肉串”状态，其中一种细胞类型围绕第二种细胞类型形成一个环。我们表明，这些独特的状态是由随着距离增加而增强的细胞吸引力（例如，当膜发生粘弹性拉伸时）导致的，而在传统的（例如分子）随着距离减小的势场中是看不到的。计算发现的大多数状态已在体外观察到，这些自组装状态在体内形态发生中可能发挥什么作用仍有待确定。
