Melnikova N B, Svitenkov A I, Hose D R, Hoekstra A G
Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, Saint Petersburg, Russia
Peter the Great State Polytechnic University, Saint Petersburg, Russia.
J R Soc Interface. 2017 Jul;14(132). doi: 10.1098/rsif.2017.0028.
A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal close-packed lattice. Tissue anisotropy is taken into account by varying interaction forces with the direction of intercellular connection. Several cell-centre interaction potentials for repulsion and attraction are considered, including the Hertz contact model and its neo-Hookean extension, the Johnson-Kendall-Roberts model of adhesive contact, and a wormlike chain model. The model is validated against data from uni-axial tension tests performed on dissected strips of tunica media. The wormlike chain potential in combination with the neo-Hookean Hertz contact model produces stress-stretch curves which represent the experimental data very well.
提出了一种基于三维细胞的冠状动脉中膜力学模型。该模型由形成六方密堆积晶格的球形细胞组成。通过改变与细胞间连接方向的相互作用力来考虑组织各向异性。考虑了几种用于排斥和吸引的细胞中心相互作用势，包括赫兹接触模型及其新胡克扩展、粘性接触的约翰逊－肯德尔－罗伯茨模型以及蠕虫状链模型。该模型根据对中膜解剖条带进行的单轴拉伸试验数据进行了验证。蠕虫状链势与新胡克赫兹接触模型相结合产生的应力－应变曲线能很好地代表实验数据。
