Shinbrot Troy
Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA.
J Theor Biol. 2006 Oct 7;242(3):764-73. doi: 10.1016/j.jtbi.2006.04.021. Epub 2006 May 9.
We present a simulation that models individual cells as spherical particles that can migrate, interact, divide and differentiate. We simulate the evolution of a progenitor layer of cells that reproduce, leading either to more progenitors or to differentiated daughters. We find that this simplified model produces spontaneous folds whose lengths depend linearly on the ratio of rates of production of progenitors to differentiated daughters. We also find that folds grow approximately exponentially in time, and that larger folds can be placed via patterning events that perturb the positions of selected progenitor cells early in the developmental process.
我们展示了一个模拟，该模拟将单个细胞建模为可以迁移、相互作用、分裂和分化的球形颗粒。我们模拟了一个细胞祖层的演化，这些细胞进行繁殖，产生更多祖细胞或分化的子代细胞。我们发现，这个简化模型会产生自发褶皱，其长度与祖细胞和分化子代细胞的产生速率之比呈线性关系。我们还发现，褶皱随时间大致呈指数增长，并且可以通过在发育过程早期扰动选定祖细胞位置的模式化事件来放置更大的褶皱。
