Krahn Michael P, Wodarz Andreas
Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain, Georg-August-Universität Göttingen, Justus-von-Liebig-Weg 11, Göttingen 37077, Germany.
Dev Cell. 2009 Aug;17(2):153-4. doi: 10.1016/j.devcel.2009.07.018.
Activation of Notch by its transmembrane ligand Delta requires the E3 ubiquitin ligases Neuralized or Mind bomb and endocytosis of the ubiquitinated ligand. In this issue of Developmental Cell, Ossipova et al. show that the polarity regulator PAR-1 phosphorylates Mind bomb, leading to the degradation of Mind bomb and to changes in cell fate due to loss of Notch signaling.
Notch通过其跨膜配体Delta激活需要E3泛素连接酶Neuralized或Mind bomb以及泛素化配体的内吞作用。在本期《发育细胞》中，奥西波娃等人表明极性调节因子PAR-1使Mind bomb磷酸化，导致Mind bomb降解，并因Notch信号缺失而导致细胞命运改变。
