Dothager Robin S, Piwnica-Worms David
Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Developmental Biology, Washington University Medical School, 510 S. Kingshighway Blvd., Box 8225 St. Louis, MO 63110, USA.
Proc Am Thorac Soc. 2009 Aug 15;6(5):403-10. doi: 10.1513/pats.200901-004AW.
Characterization and noninvasive measurement of molecular pathways and biochemistry in living cells, animal models, and humans at the cellular and molecular level is now possible using remote imaging detectors. Positron and single photon emission tomography scanners, highly sensitive cameras for bioluminescence and fluorescence imaging, as well as high-magnetic-field magnetic resonance imaging scanners, can be used to study such diverse processes as signal transduction, receptor density and function, host response to pathogens, cell trafficking, and gene transfer. In many cases, images from more than one modality can be fused, allowing structure-function and multifunction relationships to be studied on a tissue-restricted or regional basis. "Molecular imaging" holds enormous potential for elucidating the molecular mechanisms of pulmonary disease and therapeutic response in intact animal models and humans.
现在，使用远程成像探测器能够在细胞和分子水平对活细胞、动物模型及人体中的分子途径和生物化学进行表征及无创测量。正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）扫描仪、用于生物发光和荧光成像的高灵敏度相机以及高磁场磁共振成像扫描仪，可用于研究诸如信号转导、受体密度与功能、宿主对病原体的反应、细胞迁移和基因转移等多种过程。在许多情况下，来自多种成像模式的图像可以融合，从而能够在组织受限或区域基础上研究结构 - 功能及多功能关系。“分子成像”在阐明完整动物模型和人体中肺部疾病的分子机制及治疗反应方面具有巨大潜力。
