Departments of Radiology and Medical Physics and University of Wisconsin Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
J Nucl Med. 2010 Feb;51(2):169-72. doi: 10.2967/jnumed.109.066878. Epub 2010 Jan 15.
RNA interference (RNAi), an effective technique for regulating or silencing specific genes, can be applied to treat various diseases. Multiple clinical trials using RNAi are ongoing, and molecular imaging can serve as a powerful tool in RNAi-based therapies. This brief review will highlight the current progress on in vivo imaging of RNAi delivery and silencing effects. Incorporation of suitable molecular imaging techniques into future RNAi-based clinical trials will provide more pieces of the puzzle, thus facilitating the transformation of RNAi into a powerful therapeutic modality in the clinic.
RNA 干扰 (RNAi) 是一种有效的调节或沉默特定基因的技术，可用于治疗多种疾病。目前正在进行多项基于 RNAi 的临床试验，而分子影像学则可以作为 RNAi 治疗的有力工具。本文简要综述了 RNAi 递药和沉默效果的体内成像的最新进展。将合适的分子影像学技术纳入未来的基于 RNAi 的临床试验中，将提供更多的信息，从而促进 RNAi 在临床上转化为一种强大的治疗方式。
