Segal M
Exp Brain Res. 1977 Jul 15;28(5):529-41. doi: 10.1007/BF00236475.
Evoked hippocampal responses to stimulation of the contralateral hippocampus were recorded in the awake rat. The effects of priming stimulation applied to the nucleus locus coeruleus and the raphe nuclei on averaged evoked hippocampal responses to the interhemispheric stimulation were measured. It was found that priming stimulation of these monoamine-containing nuclei caused the formation of a late component in the interhemispheric potential without affecting the magnitude of the initial response component. Drugs which selectively interfere with noradrenergic or serotonergic transmission, antagonized the locus coeruleus or raphe primed late response component, respectively. Parenteral administration of d-amphetamine or l-amphetamine caused the appearance of a late response component which was similar to that seen after brainstem priming stimulation. It is suggested that the monoamines modify responses to afferent stimulation of particular pathways in the brain.
在清醒大鼠中记录了海马对侧海马刺激诱发的反应。测量了对蓝斑核和中缝核施加启动刺激对海马对半球间刺激的平均诱发反应的影响。发现对这些含单胺核的启动刺激导致半球间电位中晚期成分的形成，而不影响初始反应成分的幅度。分别选择性干扰去甲肾上腺素能或血清素能传递的药物，拮抗蓝斑核或中缝核启动的晚期反应成分。腹腔注射右旋苯丙胺或左旋苯丙胺导致出现类似于脑干启动刺激后所见的晚期反应成分。提示单胺类物质可改变大脑中特定通路传入刺激的反应。
