Segal M
Exp Brain Res. 1977 Sep 28;29(3-4):553-65. doi: 10.1007/BF00236192.
The responses of the hippocampus of the awake rat to stimulation of one of its afferent pathways were measured during classical conditioning. It was found that when the contralateral hippocampus is stimulated concurrently with the presentation of a conditioned stimulus preceding either food or an aversive shock, a late (30-40 msec) negative component in the averaged evoked response can be recorded. This late component was absent when the interhemispheric stimulation was applied prior to presentation of a conditioned stimulus or when the rat was satiated or pretreated with drugs which interfere with noradrenergic or serotonergic neurotransmission. It is suggested that classical conditioning changes neurotransmission in certain pathways in the brain and that the monoamines are involved in mediation of this change.
在经典条件反射过程中，对清醒大鼠海马体对其一条传入通路刺激的反应进行了测量。结果发现，当在呈现食物或厌恶性电击之前的条件刺激时，对侧海马体同时受到刺激，在平均诱发反应中可记录到一个晚期（30 - 40毫秒）负成分。当在条件刺激呈现之前进行半球间刺激时，或者当大鼠饱食或用干扰去甲肾上腺素能或血清素能神经传递的药物预处理时，这个晚期成分不存在。有人提出，经典条件反射会改变大脑某些通路中的神经传递，并且单胺类物质参与了这种变化的介导过程。
