Okuma Hirohisa, Kitagawa Yasuhisa, Ishikawa Tatsuya, Takagi Shigeharu
Department of Neurology, Tokai University Tokyo Hospital.
Intern Med. 2009;48(16):1351-5. doi: 10.2169/internalmedicine.48.2232. Epub 2009 Aug 17.
This study was carried out to clarify the relationship of IgG phosphatidylserine-dependent anti-prothrombin antibody (aPS/PT), IgG beta 2 glycoprotein I-dependent anticardiolipin antibody (beta 2-GPI aCL), and lupus anticoagulant (LA) to cerebral infarction, using data from 93 patients who visited our hospitals.
We computed the positive rates for each of IgG aPS/PT, beta 2-GPI aCL, and LA in the 93 patients with cerebral infarction, and carried out logistic regression analysis with IgG aPS/PT as the outcome variable and with beta 2-GPI aCL, LA, and each risk factor as predictor variables in order to assess the relationship of IgG aPS/PT with each factor.
IgG aPS/PT was more highly correlated with LA than beta 2-GPI aCL in IgG aPS/PT-positive patients with cerebral infarction. IgG aPS/PT itself appears to have high specificity as a marker for antiphospholipid syndrome (APS), because there were patients who were IgG aPS/PT-positive but both beta 2-GPI aCL- and LA-negative.
In IgG aPS/PT-positive patients with cerebral infarction, IgG aPS/PT is more highly correlated with LA than beta 2-GPI aCL. It is also strongly associated with APS. Measurement of IgG aPS/PT in patients with cerebral infarction could be of diagnostic value.
本研究利用93例来我院就诊患者的数据，旨在阐明IgG磷脂酰丝氨酸依赖性抗凝血酶原抗体（aPS/PT）、IgGβ2糖蛋白I依赖性抗心磷脂抗体（β2-GPI aCL）和狼疮抗凝物（LA）与脑梗死的关系。
我们计算了93例脑梗死患者中IgG aPS/PT、β2-GPI aCL和LA各自的阳性率，并以IgG aPS/PT作为结果变量，以β2-GPI aCL、LA和各危险因素作为预测变量进行逻辑回归分析，以评估IgG aPS/PT与各因素的关系。
在IgG aPS/PT阳性的脑梗死患者中，IgG aPS/PT与LA的相关性高于与β2-GPI aCL的相关性。IgG aPS/PT本身似乎作为抗磷脂综合征（APS）的标志物具有高特异性，因为存在IgG aPS/PT阳性但β2-GPI aCL和LA均为阴性的患者。
在IgG aPS/PT阳性的脑梗死患者中，IgG aPS/PT与LA的相关性高于与β2-GPI aCL的相关性。它也与APS密切相关。检测脑梗死患者的IgG aPS/PT可能具有诊断价值。
