• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

含共轭亚油酸的甘油二酯对C57BL/6J ob/ob小鼠的抗肥胖活性。

Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice.

作者信息

Hue Jin-Joo, Lee Ki-Nam, Jeong Jae-Hwang, Lee Sang-Hwa, Lee Young Ho, Jeong Seong-woon, Nam Sang Yoon, Yun Young Won, Lee Beom Jun

机构信息

College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea.

出版信息

J Vet Sci. 2009 Sep;10(3):189-95. doi: 10.4142/jvs.2009.10.3.189.

DOI:10.4142/jvs.2009.10.3.189
PMID:19687618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2801123/
Abstract

This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p < 0.01). All test solutions significantly decreased the levels of triglyceride, glucose and free fatty acids in the serum compared with control (p < 0.05). The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p < 0.05). CLA significantly decreased weights of renal and epididymal fats compared with the control (p < 0.05). DG and DGCLA also significantly decreased the epididymal fat weights compared with the control (p < 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism.

摘要

本研究旨在探讨含有22%共轭亚油酸（CLA）的甘油二酯（DG）-共轭亚油酸对C57BL/6J ob/ob雄性小鼠的抗肥胖作用。实验分为四组，分别为溶剂对照组、DG组、CLA组和DG-CLA组。以750mg/kg的剂量将测试溶液每天口服给予小鼠，持续5周。与对照组相比，CLA处理在整个实验期间显著降低了肥胖小鼠的平均体重（p<0.01）。与对照组相比，所有测试溶液均显著降低了血清中甘油三酯、葡萄糖和游离脂肪酸的水平（p<0.05）。与对照组相比，DG组和DG-CLA组的总胆固醇水平也显著降低（p<0.05）。与对照组相比，CLA显著降低了肾脏和附睾脂肪的重量（p<0.05）。与对照组相比，DG和DG-CLA也显著降低了附睾脂肪的重量（p<0.05）。与对照组相比，用DG、CLA和DG-CLA处理的小鼠肝脏中脂滴和脂肪球的数量显著减少。DG和CLA处理实际上增加了过氧化物酶体增殖物激活受体γ的表达。这些结果表明，含有22%CLA的DG-CLA通过控制血脂和脂肪代谢具有显著的抗肥胖作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/b77ff09ff6a2/jvs-10-189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/13785aee25f3/jvs-10-189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/cea0e0628964/jvs-10-189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/3c1c1760fcfc/jvs-10-189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/9b777c6f60b3/jvs-10-189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/b77ff09ff6a2/jvs-10-189-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/13785aee25f3/jvs-10-189-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/cea0e0628964/jvs-10-189-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/3c1c1760fcfc/jvs-10-189-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/9b777c6f60b3/jvs-10-189-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/590c/2801123/b77ff09ff6a2/jvs-10-189-g005.jpg

相似文献

1
Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice.含共轭亚油酸的甘油二酯对C57BL/6J ob/ob小鼠的抗肥胖活性。
J Vet Sci. 2009 Sep;10(3):189-95. doi: 10.4142/jvs.2009.10.3.189.
2
Rosiglitazone Improves Insulin Resistance Mediated by 10,12 Conjugated Linoleic Acid in a Male Mouse Model of Metabolic Syndrome.罗格列酮改善代谢综合征雄性小鼠模型中由10,12-共轭亚油酸介导的胰岛素抵抗。
Endocrinology. 2017 Sep 1;158(9):2848-2859. doi: 10.1210/en.2017-00213.
3
Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice.罗格列酮与共轭亚油酸联合对高脂喂养小鼠肥胖、胰岛素敏感性及肝脂肪变性的影响
Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1671-82. doi: 10.1152/ajpgi.00523.2006. Epub 2007 Feb 22.
4
Antiobesity effect of PEGylated conjugated linoleic acid on high-fat diet-induced obese C57BL/6J (ob/ob) mice: attenuation of insulin resistance and enhancement of antioxidant defenses.聚乙二醇化共轭亚油酸对高脂饮食诱导的肥胖C57BL/6J（ob/ob）小鼠的抗肥胖作用：减轻胰岛素抵抗并增强抗氧化防御能力。
J Nutr Biochem. 2009 Mar;20(3):187-94. doi: 10.1016/j.jnutbio.2008.02.001. Epub 2008 Jul 7.
5
Incorporation of conjugated linoleic acid into brain lipids is not necessary for conjugated linoleic acid-induced reductions in feed intake or body fat in mice.共轭亚油酸掺入大脑脂质对于共轭亚油酸降低小鼠采食量或体脂并不是必需的。
Nutr Res. 2012 Nov;32(11):827-36. doi: 10.1016/j.nutres.2012.10.003. Epub 2012 Nov 6.
6
Conjugated linoleic acid reduces body weight gain in ovariectomized female C57BL/6J mice.共轭亚油酸可减少去卵巢 C57BL/6J 雌性小鼠的体重增加。
Nutr Res. 2010 Oct;30(10):714-21. doi: 10.1016/j.nutres.2010.09.001.
7
Conjugated linoleic acid (CLA) prevents body fat accumulation and weight gain in an animal model.共轭亚油酸（CLA）在动物模型中可防止体脂堆积和体重增加。
J Food Sci. 2007 Oct;72(8):S612-7. doi: 10.1111/j.1750-3841.2007.00477.x.
8
Diacylglycerol-enriched structured lipids containing CLA and capric acid alter body fat mass and lipid metabolism in rats.富含共轭亚油酸（CLA）和癸酸的二酰甘油结构脂质可改变大鼠的体脂量和脂质代谢。
Ann Nutr Metab. 2006;50(3):219-28. doi: 10.1159/000090765. Epub 2006 Jan 11.
9
Effects of trans-10,cis-12 conjugated linoleic acid on body composition in genetically obese mice.反式-10，顺式-12共轭亚油酸对遗传性肥胖小鼠身体成分的影响。
J Med Food. 2009 Feb;12(1):56-63. doi: 10.1089/jmf.2008.0110.
10
Trans-10,cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genes.反式-10，顺式-12共轭亚油酸可降低小鼠肝脏脂质并减少脂肪组织脂质：特定脂质代谢基因的可能作用
Lipids. 2003 May;38(5):497-504. doi: 10.1007/s11745-003-1090-0.

引用本文的文献

1
Hepatic Lipidomics Unravels the Lipid-Lowering and Anti-Obesity Efficacy of Diacylglycerol Oil: Mechanistic Insights From High-Fat Diet-Induced Obese Mice.肝脏脂质组学揭示二酰甘油油的降脂和抗肥胖功效：来自高脂饮食诱导的肥胖小鼠的机制见解
Food Sci Nutr. 2025 Jun 13;13(6):e70395. doi: 10.1002/fsn3.70395. eCollection 2025 Jun.
2
Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots.肥胖会增加 DNA 重复介导的内源性突变热点的基因组不稳定性。
Nat Commun. 2024 Jul 23;15(1):6213. doi: 10.1038/s41467-024-50006-8.
3
Lipidome remodeling activities of DPA-EA in palmitic acid-stimulated HepG2 cells and the anti-obesity effect of the DPA-EA and DHA-EA mixture prepared from algae oil.

本文引用的文献

1
Prevalence of overweight and obesity in the United States, 1999-2004.1999 - 2004年美国超重和肥胖的患病率
JAMA. 2006 Apr 5;295(13):1549-55. doi: 10.1001/jama.295.13.1549.
2
Epidemiologic aspects of overweight and obesity in the United States.美国超重和肥胖的流行病学特征
Physiol Behav. 2005 Dec 15;86(5):599-602. doi: 10.1016/j.physbeh.2005.08.050. Epub 2005 Oct 19.
3
Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment.反式10，顺式12共轭亚油酸在脂肪细胞分化过程中对脂质积累的抑制作用取决于处理的时间和时长。
二十二碳五烯酸乙酯（DPA-EA）在棕榈酸刺激的HepG2细胞中的脂质组重塑活性以及由藻油制备的DPA-EA和二十二碳六烯酸乙酯（DHA-EA）混合物的抗肥胖作用。
Front Pharmacol. 2023 Mar 29;14:1146276. doi: 10.3389/fphar.2023.1146276. eCollection 2023.
4
Enhances Egg Quality and the Lipid Profile of Egg Yolk by Improving Lipid Metabolism.通过改善脂质代谢提高鸡蛋品质和蛋黄脂质谱。
Front Microbiol. 2022 Jul 19;13:927245. doi: 10.3389/fmicb.2022.927245. eCollection 2022.
5
Long term conjugated linoleic acid supplementation modestly improved growth performance but induced testicular tissue apoptosis and reduced sperm quality in male rabbit.长期补充共轭亚油酸可适度改善生长性能，但会诱导雄性兔睾丸组织凋亡，降低精子质量。
PLoS One. 2020 Jan 10;15(1):e0226070. doi: 10.1371/journal.pone.0226070. eCollection 2020.
6
Chrysanthemum indicum L. ethanol extract reduces high-fat diet-induced obesity in mice.野菊花乙醇提取物可减轻高脂饮食诱导的小鼠肥胖。
Exp Ther Med. 2018 Jun;15(6):5070-5076. doi: 10.3892/etm.2018.6042. Epub 2018 Apr 10.
7
Anti-obesity and anti-diabetic effects of a standardized potato extract in / mice.标准化马铃薯提取物对小鼠的抗肥胖和抗糖尿病作用
Exp Ther Med. 2016 Jul;12(1):354-364. doi: 10.3892/etm.2016.3256. Epub 2016 Apr 14.
Biochim Biophys Acta. 2005 Feb 21;1687(1-3):11-22. doi: 10.1016/j.bbalip.2004.08.018.
4
Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation.用共轭亚油酸对遗传性肥胖小鼠进行长期治疗可改善葡萄糖耐量并降低血浆胰岛素浓度：可能与过氧化物酶体增殖物激活受体（PPAR）的激活有关。
Lipids Health Dis. 2005 Jan 10;4:3. doi: 10.1186/1476-511X-4-3.
5
Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly affect body composition and energy balance in mice.作为游离脂肪酸和三酰甘油的膳食共轭亚油酸对小鼠的身体组成和能量平衡有相似的影响。
J Nutr. 2003 Oct;133(10):3181-6. doi: 10.1093/jn/133.10.3181.
6
Conjugated linoleic acid in humans: regulation of adiposity and insulin sensitivity.人体中的共轭亚油酸：对肥胖和胰岛素敏感性的调节
J Nutr. 2003 Oct;133(10):3041-6. doi: 10.1093/jn/133.10.3041.
7
Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolism.膳食二酰甘油对C57BL/6J小鼠的抗肥胖作用：膳食二酰甘油刺激肠道脂质代谢。
J Lipid Res. 2002 Aug;43(8):1312-9.
8
PPARs: transcriptional effectors of fatty acids and their derivatives.过氧化物酶体增殖物激活受体：脂肪酸及其衍生物的转录效应因子。
Cell Mol Life Sci. 2002 May;59(5):790-8. doi: 10.1007/s00018-002-8467-x.
9
PPARs: transcription factors controlling lipid and lipoprotein metabolism.过氧化物酶体增殖物激活受体：控制脂质和脂蛋白代谢的转录因子。
Ann N Y Acad Sci. 2002 Jun;967:7-18. doi: 10.1111/j.1749-6632.2002.tb04258.x.
10
Increased energy metabolism and suppressed body fat accumulation in mice by a low concentration of conjugated linoleic acid.
Biosci Biotechnol Biochem. 2001 Oct;65(10):2200-4. doi: 10.1271/bbb.65.2200.