McBride David I, Collins James J, Humphry Noel F, Herbison Peter, Bodner Ken M, Aylward Lesa L, Burns Carol J, Wilken Michael
Preventive and Social Medicine, University of Otago, Dunedin, New Zealand.
J Occup Environ Med. 2009 Sep;51(9):1049-56. doi: 10.1097/JOM.0b013e3181b571ae.
We examined the overall mortality rates of 1599 workers employed between 1969 and 1988 at a New Zealand site, which manufactured trichlorophenol.
We developed exposure estimates for 2,3,7,8-tetrachlorodibenzo-p-dioxin from a serum dioxin evaluation and used standardized mortality ratios (SMR) and proportional hazards models to evaluate risk from exposure.
Among exposed workers, deaths from total cancers (SMR = 1.1, 95% confidence intervals [CI]: 0.9-1.4), non-Hodgkin lymphoma (SMR = 1.6, 95% CI: 03-4.7), and ischemic heart disease (SMR = 1.1, 95% CI: 0.9-1.5) were slightly greater than expected, whereas deaths from lung cancer (SMR = 0.8, 95% CI: 0.4-1.5) were less than expected. We observed no significant trends with exposure levels.
Although this study is small, we found no increasing trend of cancer or disease risk with increasing 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure with the possible exception of all cancers combined.
我们调查了1969年至1988年期间在新西兰一家生产三氯苯酚的工厂工作的1599名工人的总体死亡率。
我们根据血清二恶英评估得出了2,3,7,8-四氯二苯并对二恶英的暴露估计值，并使用标准化死亡比（SMR）和比例风险模型来评估暴露风险。
在暴露工人中，总癌症死亡（SMR = 1.1，95%置信区间[CI]：0.9 - 1.4）、非霍奇金淋巴瘤死亡（SMR = 1.6，95% CI：0.3 - 4.7）和缺血性心脏病死亡（SMR = 1.1，95% CI：0.9 - 1.5）略高于预期，而肺癌死亡（SMR = 0.8，95% CI：0.4 - 1.5）低于预期。我们未观察到与暴露水平的显著趋势。
尽管本研究规模较小，但我们发现除所有癌症合并情况外，随着2,3,7,8-四氯二苯并对二恶英暴露增加，癌症或疾病风险没有增加趋势。
