Lansink Carien S, Goltstein Pieter M, Lankelma Jan V, McNaughton Bruce L, Pennartz Cyriel M A
Swammerdam Institute for Life Sciences-Center for Neuroscience, University of Amsterdam, Amsterdam, the Netherlands.
PLoS Biol. 2009 Aug;7(8):e1000173. doi: 10.1371/journal.pbio.1000173. Epub 2009 Aug 18.
Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, hippocampal-striatal ensembles reactivated together during sleep. This process was especially strong in pairs in which the hippocampal cell processed spatial information and ventral striatal firing correlated to reward. Replay was dominated by cell pairs in which the hippocampal "place" cell fired preferentially before the striatal reward-related neuron. Our results suggest a plausible mechanism for consolidating place-reward associations and are consistent with a central tenet of consolidation theory, showing that the hippocampus leads reactivation in a projection area.
将空间位置与奖励联系起来对于在自然环境中生存至关重要，并且需要海马体和腹侧纹状体的完整性。在对这些区域进行的联合多神经元记录中，海马-纹状体神经元群在睡眠期间共同重新激活。在海马体细胞处理空间信息且腹侧纹状体放电与奖励相关的配对中，这个过程尤为强烈。回放主要由海马“位置”细胞在纹状体奖励相关神经元之前优先放电的细胞对主导。我们的结果提出了一种巩固位置-奖励关联的合理机制，并且与巩固理论的一个核心原则一致，表明海马体在投射区域中引领重新激活。
