Institut National de la Santé et de la Recherche Médicale (INSERM), Imagerie Cérébrale et Handicaps Neurologiques UMR 825, CHU Purpan, Toulouse, France.
PLoS One. 2009 Aug 18;4(8):e6675. doi: 10.1371/journal.pone.0006675.
Neuropsychological data about the forms of acquired reading impairment provide a strong basis for the theoretical framework of the dual-route cascade (DRC) model which is predictive of reading performance. However, lesions are often extensive and heterogeneous, thus making it difficult to establish precise functional anatomical correlates. Here, we provide a connective neural account in the aim of accommodating the main principles of the DRC framework and to make predictions on reading skill. We located prominent reading areas using fMRI and applied structural equation modeling to pinpoint distinct neural pathways. Functionality of regions together with neural network dissociations between words and pseudowords corroborate the existing neuroanatomical view on the DRC and provide a novel outlook on the sub-regions involved. In a similar vein, congruent (or incongruent) reliance of pathways, that is reliance on the word (or pseudoword) pathway during word reading and on the pseudoword (or word) pathway during pseudoword reading predicted good (or poor) reading performance as assessed by out-of-magnet reading tests. Finally, inter-individual analysis unraveled an efficient reading style mirroring pathway reliance as a function of the fingerprint of the stimulus to be read, suggesting an optimal pattern of cerebral information trafficking which leads to high reading performance.
关于获得性阅读障碍形式的神经心理学数据为预测阅读表现的双重通路级联（DRC）模型的理论框架提供了坚实的基础。然而，病变通常广泛且异质，因此难以建立精确的功能解剖学相关性。在这里，我们提供了一个连接性的神经解释，旨在适应 DRC 框架的主要原则，并对阅读技能做出预测。我们使用 fMRI 定位了突出的阅读区域，并应用结构方程模型来确定不同的神经通路。区域的功能以及单词和伪词之间的神经网络分离证实了 DRC 的现有神经解剖学观点，并为所涉及的子区域提供了新的视角。同样，通路的一致性（或不一致性）依赖，即在单词阅读时依赖单词（或伪词）通路，在伪词阅读时依赖伪词（或单词）通路，预测了使用磁体外阅读测试评估的良好（或差）阅读表现。最后，个体间分析揭示了一种有效的阅读方式，反映了作为要阅读的刺激指纹的函数的通路依赖，这表明了一种导致高阅读表现的大脑信息传输的最佳模式。
