Nosrati-Zarenoe Ramesh, Hansson Magnus, Hultcrantz Elisabeth
Department of Clinical and Experimental Medicine, Division of Otorhinolaryngology, Linköping University, Linköping.
Acta Otolaryngol. 2010 Mar;130(3):384-91. doi: 10.1080/00016480903161541.
Results from a database for sudden sensorineural hearing loss (SSNHL) demonstrate no correlation between laboratory findings, treatment, and outcome in 400 patients. The patients with pathological test results were not treated differently from those with normal test results. The value of laboratory findings and MRI might increase if the results are categorized to more specific diagnoses.
To investigate diagnostic test batteries for SSNHL and evaluate their value in the management of idiopathic SSNHL.
A total of 400 patients submitted to the Swedish national database for SSNHL were analyzed. Information was collected about the patient's past medical history, potential precipitating events, trauma, medical history, hearing loss, current disease, diagnostic protocol, and treatment, using questionnaires as well as two audiograms, one at the first ENT clinic visit and another 3 months later.
In all, 65% of these 400 patients underwent hematological tests and 40% had an MRI/CT scan. Twenty-two of 160 MRI investigated had pathological findings including 5 acoustic neuromas. Also, 300 of these 400 patients were evaluated as having idiopathic sudden sensorineural hearing loss (ISSNHL); 24% of them had one or more pathological test results. No significant correlation was found between either the MRI findings or the laboratory findings with regard to treatment or hearing recovery in patients with ISSNHL.
突发性感音神经性听力损失（SSNHL）数据库的结果表明，400例患者的实验室检查结果、治疗与预后之间无相关性。病理检查结果异常的患者与检查结果正常的患者治疗方式并无不同。如果将结果分类为更具体的诊断，实验室检查结果和磁共振成像（MRI）的价值可能会增加。
研究SSNHL的诊断检查组合，并评估其在特发性SSNHL治疗中的价值。
对瑞典国家SSNHL数据库中的400例患者进行了分析。通过问卷调查以及两次听力图收集患者的既往病史、潜在诱发事件、创伤、病史、听力损失、当前疾病、诊断方案和治疗信息，一次听力图在首次耳鼻喉科门诊就诊时进行，另一次在3个月后进行。
这400例患者中，65%接受了血液学检查，40%进行了MRI/CT扫描。160例接受MRI检查的患者中有22例有病理结果，其中包括5例听神经瘤。此外，这400例患者中有300例被评估为患有特发性突发性感音神经性听力损失（ISSNHL）；其中24%有一项或多项病理检查结果。在ISSNHL患者中，MRI结果或实验室检查结果与治疗或听力恢复之间均未发现显著相关性。
