仅使用孕激素避孕药的尼日利亚使用者中的异常可沉淀球蛋白（GAP）

Globulines anormalment precipitables (GAP) in Nigerian users of progestogen-only pill.

作者信息

Wright E A, Temple V J, Kapu M M, Mwaigwe M M

机构信息

Department of Obstetrics and Gynaecology, Faculty of Medical Sciences, University of Jos, Nigeria.

出版信息

Int J Gynaecol Obstet. 1990 Feb;31(2):163-5. doi: 10.1016/0020-7292(90)90715-w.

DOI:10.1016/0020-7292(90)90715-w

PMID:1968864

Abstract

The globulines anormalment precipitables (GAP), which have been reported to be raised in current and former oral contraceptive users, were measured in Nigerian subjects which included male volunteers. The results showed that GAP were present in males who had never used contraceptives and that the mean values were lowest in intrauterine contraceptive device (IUD) users and highest in females who had never used any contraceptives. However, current contraceptive users had lower mean GAP values than either former users or never users. It was therefore concluded that GAP levels alone cannot be used to predict the development of thromboembolic complications in pill users, and that ethinyl estradiol cannot be the main physiological stimulus for GAP synthesis.

摘要

异常可沉淀球蛋白（GAP）在目前及既往口服避孕药使用者中据报道会升高，在包括男性志愿者在内的尼日利亚受试者中对其进行了测量。结果显示，从未使用过避孕药的男性体内存在GAP，其平均值在宫内节育器（IUD）使用者中最低，在从未使用过任何避孕药的女性中最高。然而，目前的避孕药使用者的GAP平均值低于既往使用者或从未使用者。因此得出结论，仅GAP水平不能用于预测避孕药使用者发生血栓栓塞并发症的情况，且炔雌醇不可能是GAP合成的主要生理刺激因素。