与CD45RA+和CD45RO+ T细胞激活相关的表型变化。
Phenotypic changes associated with activation of CD45RA+ and CD45RO+ T cells.
作者信息
Wallace D L, Beverley P C
机构信息
ICRF Human Tumour Immunology Group, Courtauld Institute of Biochemistry, London.
出版信息
Immunology. 1990 Mar;69(3):460-7.
Abstract
Resting CD45RO+, mature/memory, T cells are phenotypically distinct from intermediate CD45RO+/CD45RA+ and CD45RA+, immature/virgin, T cells, and are characterized by high levels of expression of a number of adhesion molecules, such as CD2, CD18, CD58 and CD29. The kinetics of up-regulation of molecules, like CD25 and CD54 associated with activation, were similar in both subsets and suggested that their high level expression was associated with later events rather than initial recognition and signal transduction. CD45RA+ T cells, unlike CD45RO+ T cells, were unable to proliferate in response to mitogenic combinations of CD2 monoclonal antibodies (mAb), although in combination with submitogenic doses of PMA both up-regulation of cell-surface molecules and proliferation occurred. In addition, recruitment of CD45RA+ T cells by CD2 mAb-activated CD45RO+ T cells can occur.
摘要
静息的CD45RO⁺成熟/记忆T细胞在表型上与中间型CD45RO⁺/CD45RA⁺和CD45RA⁺未成熟/初始T细胞不同，其特征在于多种黏附分子的高表达水平，如CD2、CD18、CD58和CD29。与激活相关的分子（如CD25和CD54）上调的动力学在两个亚群中相似，这表明它们的高表达水平与后期事件相关，而非初始识别和信号转导。与CD45RO⁺ T细胞不同，CD45RA⁺ T细胞不能对CD2单克隆抗体（mAb）的促有丝分裂组合产生增殖反应，尽管与亚致有丝分裂剂量的佛波酯联合使用时，细胞表面分子会上调且会发生增殖。此外，CD2 mAb激活的CD45RO⁺ T细胞可招募CD45RA⁺ T细胞。
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本文引用的文献
1
Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3.与人类T淋巴细胞介导的细胞溶解相关的三种不同抗原：淋巴细胞功能相关抗原-1（LFA-1）、淋巴细胞功能相关抗原-2（LFA-2）和淋巴细胞功能相关抗原-3（LFA-3）。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7489-93. doi: 10.1073/pnas.79.23.7489.
2
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor.一种似乎能识别人类T细胞生长因子受体的单克隆抗体；该受体的部分特性
Nature. 1982 Nov 18;300(5889):267-9. doi: 10.1038/300267a0.
3
Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.通过E玫瑰花结形成或单克隆抗T细胞抗体所界定的人“T”淋巴细胞的独特功能特性。
Eur J Immunol. 1981 Apr;11(4):329-34. doi: 10.1002/eji.1830110412.
4
Monoclonal antibodies specific for human monocytes, granulocytes and endothelium.对人类单核细胞、粒细胞和内皮细胞具有特异性的单克隆抗体。
Immunology. 1984 Dec;53(4):753-67.
5
A human lymphocyte-associated antigen involved in cell-mediated lympholysis.一种参与细胞介导性淋巴细胞溶解的人类淋巴细胞相关抗原。
Eur J Immunol. 1983 Mar;13(3):202-8. doi: 10.1002/eji.1830130305.
6
Phorbol diester receptor copurifies with protein kinase C.佛波酯受体与蛋白激酶C共纯化。
Proc Natl Acad Sci U S A. 1983 Jan;80(1):36-40. doi: 10.1073/pnas.80.1.36.
7
Phenomenon of human T cells rosetting with sheep erythrocytes analyzed with monoclonal antibodies. "Modulation" of a partially hidden epitope determining the conditions of interaction between T cells and erythrocytes.用单克隆抗体分析人T细胞与绵羊红细胞的玫瑰花结现象。决定T细胞与红细胞间相互作用条件的部分隐蔽表位的“调节” 。
J Exp Med. 1982 May 1;155(5):1317-33. doi: 10.1084/jem.155.5.1317.
8
Characterization of a human B lymphocyte-specific antigen.一种人类B淋巴细胞特异性抗原的特性描述。
J Immunol. 1980 Oct;125(4):1678-85.
9
Adhesion of T lymphocytes to human endothelial cells is regulated by the LFA-1 membrane molecule.
J Cell Physiol. 1986 Feb;126(2):285-90. doi: 10.1002/jcp.1041260219.
10
The isolation and characterization of the human helper inducer T cell subset.人类辅助诱导性T细胞亚群的分离与鉴定。
J Immunol. 1985 Jun;134(6):3762-9.
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