Rumyantseva Olga A, Olkhovskiy Igor A, Malysheva Marina A, Ruzaeva Ludmila A, Vasiliev Alexander V, Kazennova Elena V, Bobkova Marina R, Lukashov Vladimir V
Krasnoyarsk Regional AIDS Center, Krasnoyarsk, Russia.
AIDS Res Hum Retroviruses. 2009 Sep;25(9):931-6. doi: 10.1089/aid.2009.0075.
To study the molecular epidemiology of HIV-1 in Krasnoyarsk region, Russia, where HIV-1 has spread rapidly since 2000, we obtained pol sequences from individuals living in this region (n = 67) as well as in the geographically closely related Altay region (n = 13). In both regions, subtype A viruses specific for the former Soviet Union (IDU-A strains) were dominant (92.5%). Virus sequences clustered according to the geographic origin of the infected individuals rather than to their risk group, demonstrating the role of geographically defined epidemiological networks in the propagation of the HIV-1 epidemic in the region. Six viruses belonged to subtype B. Three of them were phylogenetically (and therefore epidemiologically) closely related to each other, demonstrating that even though IDU-A viruses dominate the epidemic, the spread of other virus strains does occur. Most viruses (75%) had an A62V mutation in reverse transcriptase, specific for HIV-1 strains in Russia. Remarkably, 26 of 47 (55%) patients under HAART with detectable virus loads did not have any known drug-resistant mutation, indicating the need to increase compliance to therapy.
为研究俄罗斯克拉斯诺亚尔斯克地区的HIV-1分子流行病学情况（自2000年以来，该地区HIV-1传播迅速），我们获取了居住在该地区的个体（n = 67）以及地理上与之紧密相关的阿尔泰地区（n = 13）个体的pol序列。在这两个地区，前苏联特有的A亚型病毒（IDU-A毒株）占主导地位（92.5%）。病毒序列根据感染个体的地理来源而非其风险组聚类，这表明地理界定的流行病学网络在该地区HIV-1疫情传播中所起的作用。六种病毒属于B亚型。其中三种在系统发育上（因此在流行病学上）彼此密切相关，这表明尽管IDU-A病毒在疫情中占主导，但其他病毒株的传播确实存在。大多数病毒（75%）在逆转录酶中有A62V突变，这是俄罗斯HIV-1毒株特有的。值得注意的是，在接受高效抗逆转录病毒治疗且病毒载量可检测的47名患者中，有26名（55%）没有任何已知的耐药突变，这表明需要提高治疗依从性。
