Soares Sandro G, Oliveira Leandro L
Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, FMRP-USP, Ribeirão Preto, SP, Brasil.
Protein Pept Lett. 2009;16(8):913-9. doi: 10.2174/092986609788923293.
Protein glycosylation represents one of the most important post-translational events, and is a mean of diversifying a protein without recourse to the genome. The venoms produced by snakes contain an abundance of glycoproteins with N-linked carbohydrates. N-linked glycosylation can ensure the correct folding of important functional domains. Characterization of carbohydrates structures aids in development of human therapeutics by snake venom toxins.
蛋白质糖基化是最重要的翻译后修饰事件之一,是一种无需借助基因组就能使蛋白质多样化的方式。蛇产生的毒液含有大量带有N-连接碳水化合物的糖蛋白。N-连接糖基化可以确保重要功能域的正确折叠。对碳水化合物结构的表征有助于蛇毒毒素在人类治疗药物方面的开发。