Cardiovascular Center, National Taiwan University Hospital, Yun-Lin Branch, Douliou, Taiwan.
Angiology. 2010 May;61(4):382-7. doi: 10.1177/0003319709344575. Epub 2009 Aug 18.
Peripheral arterial disease (PAD) is an inflammatory process. The association between white blood cell (WBC) count and PAD in those with and without traditional risk factors is not clear. We examined data from the National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. A total of 5260 participants were included. The result showed that the prevalence of PAD rose from 2.8% +/- 0.5% in the lowest quartile of plasma WBC count to 8.0% +/- 1.2% in the highest quartile. In subgroup analysis, the graded association between WBC count and PAD was significant in patients without hypertension, diabetes, smoking, chronic kidney disease (CKD), and in patients with or without hypercholesterolemia but not significant in patients with hypertension, smoking, diabetes, or CKD. In those without hypertension, diabetes, smoking, or CKD, the cutoff value for WBC count was 6.75 x 10(9)/L. We concluded that the positive association between WBC count and PAD can be demonstrated in this national survey.
外周动脉疾病 (PAD) 是一种炎症过程。在有或没有传统危险因素的人群中，白细胞 (WBC) 计数与 PAD 之间的关联尚不清楚。我们检查了 1999 年至 2004 年全国健康和营养检查调查 (NHANES) 的数据。共有 5260 名参与者被纳入研究。结果显示，PAD 的患病率从最低四分位的血浆 WBC 计数的 2.8% +/- 0.5%上升到最高四分位的 8.0% +/- 1.2%。在亚组分析中，在没有高血压、糖尿病、吸烟、慢性肾脏病 (CKD) 的患者以及有或没有高胆固醇血症的患者中，WBC 计数与 PAD 之间呈梯度关联，但在高血压、吸烟、糖尿病或 CKD 的患者中则不显著。在没有高血压、糖尿病、吸烟或 CKD 的患者中，WBC 计数的截断值为 6.75 x 10(9)/L。我们的结论是，在这项全国性调查中可以证明白细胞计数与 PAD 之间存在正相关关系。
