症状性外周动脉疾病患者下肢大截肢的危险因素：一项回顾性队列研究
Risk factors of major lower limb amputation in symptomatic peripheral artery disease: a retrospective cohort study.
作者信息
Prasertcharoensuk Supatcha, Prateepphuangrat Krittin, Angkasith Phati, Teeratakulpisarn Panu, Tanmit Parichat, Chimluang Saowapa, Sawanyawisuth Kittisak, Wongkonkitsin Narongchai
机构信息
Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Operating Room of Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
出版信息
Future Sci OA. 2025 Dec;11(1):2476881. doi: 10.1080/20565623.2025.2476881. Epub 2025 Mar 13.
AIM
To find risk factors of major amputation in patients with peripheral artery disease (PAD) by a combination of both personal risk factors and treatment.
METHODS
This was a retrospective cohort study enrolled adult patients diagnosed as symptomatic PAD. Predictors for major amputation were analyzed.
RESULTS
There were 221 patients with PAD met the study criteria; 28 patients (12.67%) had major amputation events. There were three independent factors Rutherford classification, white blood cell, and serum albumin. The adjusted odds ratio (95% confidence interval) of these factors were 1.824 (1.118, 2.976), 1.073 (1.019, 1.131), and 0.421 (0.202, 0.879), respectively.
CONCLUSIONS
Serum albumin was modifiable to prevent future major amputation in patients with PAD.
目的
通过综合个人风险因素和治疗方法来寻找外周动脉疾病（PAD）患者大截肢的风险因素。
方法
这是一项纳入被诊断为有症状PAD的成年患者的回顾性队列研究。分析了大截肢的预测因素。
结果
有221例PAD患者符合研究标准；28例（12.67%）发生了大截肢事件。有三个独立因素：卢瑟福分类、白细胞和血清白蛋白。这些因素的调整优势比（95%置信区间）分别为1.824（1.118，2.976）、1.073（1.019，1.131）和0.421（0.202，0.879）。
结论
血清白蛋白是可调节的，以预防PAD患者未来发生大截肢。
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