University of Lund, Vascular Centre, Malmö University Hospital, Malmö, Sweden.
Angiology. 2010 May;61(4):324-8. doi: 10.1177/0003319709344190. Epub 2009 Aug 18.
The etiology of abdominal aortic aneurysm (AAA) includes inflammation and endothelial dysfunction. To evaluate relations between these mechanisms and AAA growth, endothelin (ET)-1, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and CD40 ligand were related to yearly AAA growth for 2.9 +/- 1.6 years (mean +/- SD) in 178 patients with conservatively followed AAA. Total number of follow-up years was 491. Abdominal aortic aneurysm diameter increased by 3.3 +/- 4.0 mm during the first year and by 4.9 +/- 4.4 mm during the first 2 years. Median (range) growth was 2.5 (-1.0 to 30.6) mm/year. When patients with AAA growth above or below median were compared, initial AAA diameter (46.1 +/- 5.8 vs 42.0 +/- 8.3 mm; P < .0001), age (75 +/- 7 vs 72 +/- 8 years; P < .029), and initial ET-1 levels (1.31 +/- 0.50 vs 1.13 +/- 0.49 pg/mL; P < .0177) were higher in patients with growth above median. Endothelin 1 (P = .0230) and initial AAA diameter (P = .0019) predicted AAA growth above median in logistic regression. In conclusion, higher initial levels of ET-1 and initial AAA diameter independently predict AAA growth.
腹主动脉瘤（AAA）的病因包括炎症和内皮功能障碍。为了评估这些机制与 AAA 生长之间的关系，在 178 例保守治疗的 AAA 患者中，将内皮素（ET）-1、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6 和 CD40 配体与 2.9 +/- 1.6 年（平均 +/- SD）的每年 AAA 生长相关联。总随访年限为 491 年。AAA 直径在第一年增加了 3.3 +/- 4.0 毫米，在头两年增加了 4.9 +/- 4.4 毫米。中位数（范围）增长率为 2.5（-1.0 至 30.6）mm/年。当比较 AAA 生长高于或低于中位数的患者时，初始 AAA 直径（46.1 +/- 5.8 与 42.0 +/- 8.3 毫米；P <.0001）、年龄（75 +/- 7 与 72 +/- 8 岁；P <.029）和初始 ET-1 水平（1.31 +/- 0.50 与 1.13 +/- 0.49 pg/mL；P <.0177）在中位数以上生长的患者中更高。在逻辑回归中，ET-1（P =.0230）和初始 AAA 直径（P =.0019）预测中位数以上的 AAA 生长。总之，较高的初始 ET-1 水平和初始 AAA 直径独立预测 AAA 生长。
