Lehrer S, Sanchez M, Song H K, Dalton J, Levine E, Savoretti P, Thung S N, Schachter B
Department of Radiotherapy, Mount Sinai School of Medicine, New York, NY 10029.
Lancet. 1990 Mar 17;335(8690):622-4. doi: 10.1016/0140-6736(90)90410-7.
To examine whether a variant human oestrogen receptor gene, which differs from the wild-type gene in the B region, was associated with spontaneous abortion, obstetric histories of breast cancer patients with this variant were compared with those of breast cancer patients with the wild-type gene. In women with the B-variant, 50% of pregnancies ended in spontaneous abortion, compared with 10% for women homozygous for the wild-type gene. B-variant women also had a higher proportion of spontaneous abortions and a higher number of spontaneous abortions per woman than did those with the wild-type gene.
为了研究一种在B区域与野生型基因不同的变异型人类雌激素受体基因是否与自然流产有关，将患有这种变异型基因的乳腺癌患者的产科病史与患有野生型基因的乳腺癌患者的产科病史进行了比较。在具有B变异型的女性中，50%的妊娠以自然流产告终，而野生型基因纯合子女性的这一比例为10%。与具有野生型基因的女性相比，具有B变异型的女性自然流产的比例更高，且每位女性的自然流产次数也更多。
