Berkowitz G S, Stone J L, Lehrer S P, Marcus M, Lapinski R H, Schachter B S
Department of Obstetrics, Gynecology, and Reproductive Science, Mount Sinai School of Medicine.
Am J Obstet Gynecol. 1994 Dec;171(6):1579-84. doi: 10.1016/0002-9378(94)90405-7.
A case-control study was undertaken to assess the association between an estrogen receptor gene variant and the risk of recurrent spontaneous abortions.
The frequency of the estrogen receptor gene variant in blood lymphocyte deoxyribonucleic acid and other selected maternal characteristics was compared among 60 primary recurrent aborters, 61 secondary recurrent aborters, and 43 women who had had at least two live births but no spontaneous abortions.
No association was evident between the estrogen receptor gene variant and the risk of either primary or secondary recurrent abortion. There were data suggesting that primary recurrent aborters in particular were more likely to report a family history of recurrent abortion and a family history of breast cancer.
These findings indicate that the estrogen receptor polymorphism is not a genetic marker for recurrent spontaneous abortions. Therefore, as suggested by previous investigations, this polymorphism appears to be a marker for breast cancer risk only among the subgroups who have had a history of repeated abortions.
开展一项病例对照研究，以评估雌激素受体基因变异与复发性自然流产风险之间的关联。
比较了60例原发性复发性流产者、61例继发性复发性流产者以及43例至少生育过两个活产儿但无自然流产史的女性的血液淋巴细胞脱氧核糖核酸中雌激素受体基因变异的频率以及其他选定的母体特征。
雌激素受体基因变异与原发性或继发性复发性流产风险之间无明显关联。有数据表明，尤其是原发性复发性流产者更有可能报告复发性流产家族史和乳腺癌家族史。
这些发现表明，雌激素受体多态性不是复发性自然流产的遗传标志物。因此，正如先前研究所表明的，这种多态性似乎仅在有反复流产史的亚组中是乳腺癌风险的标志物。
