Department of Obstetrics, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001.
Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001.
Biosci Rep. 2019 Feb 8;39(2). doi: 10.1042/BSR20181548. Print 2019 Feb 28.
This meta-analysis was performed in order to determine the associations between the estrogen receptor α (ESR1) gene PvuII site (-397T/C, rs2234693) and XbaI site (-351A/G, rs9340799) polymorphisms with severe and mild pre-eclampsia. Eligible studies were identified by searching PubMed, Medline, Embase, China National Knowledge Infrastructure (CNKI), and WanFang databases until May 2018. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to calculate the associations. Six articles (consisting of seven studies; one article was considered as two separate studies with two different subpopulations) investigated the ESR1 gene PvuII -397T/C and XbaI -351A/G polymorphisms in severe and mild pre-eclampsia patients and included controls. The pooled results indicated an increased risk of severe pre-eclampsia for the XbaI -351A/G polymorphism (OR = 1.67, 95% CI = 1.10-2.25, =0.017 for GG compared with AA+GA; OR = 1.81, 95% CI = 1.17-2.82, =0.008 for GG compared with GA). The GG genotype of the ESR1 XbaI polymorphism could be a genetic risk factor for severe pre-eclampsia susceptibility. However, the ESR1 gene PvuII -397T/C polymorphism was not significantly associated with the risk of severe pre-eclampsia, and there was no association between mild pre-eclampsia and the ESR1 gene PvuII -397T/C and XbaI -351A/G polymorphisms separately. The current meta-analysis indicates that the ESR1 XbaI genetic polymorphism may be associated with severe pre-eclampsia. However, there was no association of the ESR1 gene PvuII and XbaI polymorphisms with the risk of mild pre-eclampsia. Owing to the low statistical power, the results may not be sufficiently robust and this conclusion should be interpreted cautiously, which highlights the requirement for large-scale and high-quality studies in this field.
本荟萃分析旨在确定雌激素受体 α（ESR1）基因 PvuII 位点（-397T/C，rs2234693）和 XbaI 位点（-351A/G，rs9340799）多态性与重度和轻度子痫前期之间的关联。通过检索 PubMed、Medline、Embase、中国知网（CNKI）和万方数据库，直到 2018 年 5 月，确定了符合条件的研究。使用合并优势比（OR）和 95%置信区间（CI）来计算关联。六项研究（包括七项研究；一篇文章被认为是具有两个不同亚群的两个独立研究）调查了 ESR1 基因 PvuII-397T/C 和 XbaI-351A/G 多态性与重度和轻度子痫前期患者和对照者。合并结果表明，XbaI-351A/G 多态性与重度子痫前期的风险增加相关（OR=1.67，95%CI=1.10-2.25，与 AA+GA 相比，=0.017；OR=1.81，95%CI=1.17-2.82，与 GA 相比，=0.008）。ESR1 XbaI 多态性的 GG 基因型可能是重度子痫前期易感性的遗传危险因素。然而，ESR1 基因 PvuII-397T/C 多态性与重度子痫前期的风险无显著相关性，并且 ESR1 基因 PvuII-397T/C 和 XbaI-351A/G 多态性与轻度子痫前期无相关性。本荟萃分析表明，ESR1 XbaI 遗传多态性可能与重度子痫前期相关。然而，ESR1 基因 PvuII 和 XbaI 多态性与轻度子痫前期的风险无关。由于统计效能较低，结果可能不够稳健，因此应谨慎解释这一结论，这突出表明需要在该领域进行大规模和高质量的研究。
