Department of Gastroenterology, Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil.
Clinics (Sao Paulo). 2009;64(8):785-90. doi: 10.1590/S1807-59322009000800013.
Several aspects of gastroesophageal reflux disease (GERD) have been studied, but the frequency of comorbidities is not yet fully understood.
To study the prevalence of GERD comorbidities in a tertiary care hospital.
We prospectively studied 670 consecutive adult patients from the outpatient department of our facility. A diagnosis was established using clinical, endoscopic and/or pHmetry-related findings. Each patient's medical file was reviewed with respect to the presence of other medical conditions and diagnoses.
Of the 670 patients, 459 (68.6%) were female, and the mean age was 55.94 (17-80 years). We registered 316 patients (47.1%) with the erosive form of GERD and 354 patients (52.9%) with the non-erosive form. A total of 1,664 instances of comorbidities were recorded in 586 patients (87.5%), with the most common being arterial hypertension (21%), hypercholesterolemia (9%), obesity (9%), type II diabetes mellitus (5%) and depression (4%). Two or more comorbidities were present in 437 individuals (64.8%). The occurrence of comorbidities increased with age and was higher in patients with the non-erosive form of GERD.
In a tertiary referral population, comorbidities were very common, and these may have worsened the already impaired health-related quality of life of these patients. Clinicians caring for GERD patients in this setting must be aware of the likelihood and nature of comorbid disorders and their impact on disease presentation and patient management.
已经研究了胃食管反流病（GERD）的多个方面，但对合并症的频率尚不完全了解。
研究三级保健医院 GERD 合并症的患病率。
我们前瞻性研究了来自我们机构门诊的 670 例连续成年患者。使用临床，内镜和/或 pH 相关发现建立诊断。对每位患者的病历进行了回顾，以了解是否存在其他医疗状况和诊断。
在 670 例患者中，有 459 例（68.6％）为女性，平均年龄为 55.94 岁（17-80 岁）。我们记录了 316 例（47.1％）有侵蚀性 GERD 和 354 例（52.9％）非侵蚀性 GERD 的患者。在 586 例（87.5％）患者中记录了 1664 例合并症，最常见的合并症是动脉高血压（21％），高胆固醇血症（9％），肥胖症（9％），II 型糖尿病（5％）和抑郁症（4％）。有 437 名患者（64.8％）存在两种或更多合并症。合并症的发生随年龄增长而增加，在非侵蚀性 GERD 患者中更为常见。
在三级转诊人群中，合并症非常普遍，这可能使已经受损的与健康相关的生活质量进一步恶化。在这种情况下照顾 GERD 患者的临床医生必须意识到合并症的可能性和性质及其对疾病表现和患者管理的影响。
