Bushi Ganesh, Gaidhane Abhay M, Vadia Nasir, Menon Soumya V, Chennakesavulu Kattela, Panigrahi Rajashree, Shabil Muhammed, Jena Diptismita, Kumar Harish, Rani Anju, Sah Sanjit, Singh Mahendra Pratap, Sahu Swastik Subhankar, Tiwari Suraj, Goh Khang Wen
Chitkara Centre for Research and Development Chitkara University Baddi India.
Faculty of Data Science and Information Technology INTI International University Nilai Malaysia.
JGH Open. 2025 Apr 12;9(4):e70158. doi: 10.1002/jgh3.70158. eCollection 2025 Apr.
Gastroesophageal reflux disease (GERD) and hypertension (HTN) are common conditions with substantial health burdens. While prior studies suggest a link between GERD and HTN, findings remain inconsistent. This systematic review and meta-analysis aimed to clarify the relationship between GERD and HTN.
A systematic search of PubMed, Web of Science, and Embase was conducted to identify observational studies published through December 2024. Studies evaluating the prevalence and association between GERD and HTN were included. Screening and data extraction were performed using Nested Knowledge software, with quality assessed via the Modified Newcastle-Ottawa Scale. Random-effects meta-analyses were used to calculate pooled prevalence and risk estimates, while heterogeneity was quantified using the statistic. Publication bias was evaluated using DOI and funnel plots.
Twelve studies, with sample sizes ranging from 71 to 12 960 participants, were included. The pooled prevalence of HTN among GERD patients was 16.80% (95% CI: 6.28%-31.02%) with high heterogeneity ( = 99%). The pooled risk ratio (RR) for HTN was 1.381 (95% CI: 0.992-1.922) and heterogeneity ( = 76%) highlighted variability. Sensitivity analyses and publication bias were evident.
GERD is a potential risk factor for HTN, with GERD patients demonstrating an elevated likelihood of developing HTN. Future research is required to investigate the underlying mechanisms and confounding factors that may influence this association.
胃食管反流病（GERD）和高血压（HTN）是常见疾病，给健康带来沉重负担。虽然先前的研究表明GERD与HTN之间存在联系，但研究结果仍不一致。本系统评价和荟萃分析旨在阐明GERD与HTN之间的关系。
对PubMed、科学网和Embase进行系统检索，以识别截至2024年12月发表的观察性研究。纳入评估GERD与HTN之间患病率及关联的研究。使用Nested Knowledge软件进行筛选和数据提取，并通过改良的纽卡斯尔-渥太华量表评估质量。采用随机效应荟萃分析计算合并患病率和风险估计值，同时使用I²统计量对异质性进行量化。使用DOI和漏斗图评估发表偏倚。
纳入12项研究，样本量从71至12960名参与者不等。GERD患者中HTN的合并患病率为16.80%（95%CI：6.28%-31.02%），异质性高（I² = 99%）。HTN的合并风险比（RR）为1.381（95%CI：0.992-1.922），异质性（I² = 76%）突出显示了变异性。敏感性分析和发表偏倚明显。
GERD是HTN的一个潜在危险因素，GERD患者患HTN的可能性升高。需要进一步研究来探究可能影响这种关联的潜在机制和混杂因素。
