Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Head Neck. 2010 May;32(5):555-61. doi: 10.1002/hed.21217.
The benefit of postoperative radiotherapy (PORT) for early squamous cell carcinoma of the tongue (SCCOT) with pathologic N1 disease remains unclear.
The medical records of all patients with pathologic T1-2/N0-1 SCCOT who underwent wide excision of the primary tumor and neck dissection between 1980 and 2002 were reviewed.
There were 59 patients analyzed, including 28 patients with and 31 patients without PORT. The 5-year disease-free survival rates were 81.2% and 53% for the patients with and without PORT, respectively (p = .03). The overall 5-year survival rates were 77% and 70.5% for the patients with and without PORT, respectively (p = .36). Multivariate analyses showed that PORT had the only protective effect (p = .01) and extracapsular spread (ECS) was the only significantly adverse factor for locoregional recurrence (p = .03).
Approximately one-third of the patients who received only surgery had locoregional recurrence. PORT significantly improved the disease-free survival.
病理 N1 期的早期舌鳞状细胞癌（SCCOT）术后放疗（PORT）的获益仍不明确。
回顾分析了 1980 年至 2002 年间所有接受原发肿瘤广泛切除术和颈部淋巴结清扫术的 T1-2/N0-1 期病理 SCCOT 患者的病历。
共分析了 59 例患者，其中 28 例接受 PORT，31 例未接受 PORT。PORT 组和未 PORT 组的 5 年无病生存率分别为 81.2%和 53%（p =.03）。PORT 组和未 PORT 组的 5 年总生存率分别为 77%和 70.5%（p =.36）。多因素分析显示，PORT 是唯一具有保护作用的因素（p =.01），而包膜外扩散（ECS）是局部区域复发的唯一显著不利因素（p =.03）。
仅接受手术治疗的患者约有三分之一出现局部区域复发。PORT 显著提高了无病生存率。
