Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
Mov Disord. 2009 Oct 30;24(14):2076-80. doi: 10.1002/mds.22694.
We aimed to investigate the prevalence of restless legs syndrome (RLS) according to essential diagnostic criteria, and to explore potential associations with clinical features, especially motor fluctuations, in a cohort of 113 patients with idiopathic Parkinson's disease (PD). Twenty-eight (24%) fulfilled essential diagnostic criteria for RLS. They were younger (63.1 +/- 8.6 vs. 68.8 +/- 9.0 years; P = 0.004), had an earlier onset of PD (54.1 +/- 9.5 vs. 59.2 +/- 10.3 years; P = 0.018), and received lower levodopa equivalent doses (578.4 +/- 382.2 vs. 779.1 +/- 459.6 mg/day; P = 0.04) than patients with PD who scored negative for RLS. In 23 patients (82%), RLS symptom onset was after PD onset (mean interval, 4.5 +/- 3.7 years). The majority (n = 17, 61%) who scored positive for RLS reported that the urge to move the legs and unpleasant sensations were associated with wearing off, raising the possibility of RLS mimics in fluctuating patients with PD.
我们旨在根据基本诊断标准调查不安腿综合征（RLS）的患病率，并探讨其与临床特征，尤其是运动波动的潜在关联，在 113 名特发性帕金森病（PD）患者的队列中进行了研究。28 名患者（24%）符合 RLS 的基本诊断标准。他们更年轻（63.1 +/- 8.6 岁对 68.8 +/- 9.0 岁；P = 0.004），PD 发病更早（54.1 +/- 9.5 岁对 59.2 +/- 10.3 岁；P = 0.018），并且接受的左旋多巴等效剂量更低（578.4 +/- 382.2 毫克对 779.1 +/- 459.6 毫克/天；P = 0.04）比 RLS 评分阴性的 PD 患者。在 23 名患者（82%）中，RLS 症状发作于 PD 发作后（平均间隔 4.5 +/- 3.7 年）。大多数（n = 17，61%）RLS 评分阳性的患者报告说腿部移动的冲动和不愉快的感觉与药物作用减退有关，这增加了 PD 波动患者中 RLS 模拟的可能性。
