Department of Neurology, University Hospitals of Leicester, Leicester, UK.
Acta Neurol Scand. 2013 Mar;127(3):216-20. doi: 10.1111/ane.12011. Epub 2012 Sep 18.
The prevalence of restless legs syndrome (RLS) has been studied extensively in Parkinson's disease (PD), with conflicting findings. More recently, both neuropathy and leg motor restlessness (LMR) have been found to be significantly more prevalent in PD patients than in controls.
Our objective was to determine whether RLS or LMR may be secondary to neuropathy, or its currently postulated determinants, cumulative levodopa usage and vitamin B(12) metabolism, in patients with PD.
We compared prevalence of RLS, LMR and neuropathy in 37 PD patients and 37 age- and gender-matched controls. Correlations between RLS/LMR and neuropathy and symptomatic neuropathy, cumulative levodopa usage and vitamin B(12) levels were ascertained.
RLS prevalence was comparable in PD patients and controls (16.2% vs 10.8%; P = 0.30). LMR was significantly more common in PD patients than in controls (40.5% vs 16.2%; P = 0.038), as was neuropathy (37.8% vs 8.1%; P = 0.005). Neither RLS, nor LMR correlated with neuropathy or symptomatic neuropathy, cumulative levodopa exposure or serum vitamin B(12) levels in patients with PD. There was a non-significant trend for a correlation between LMR and earlier age of onset of PD (P = 0.069).
RLS and LMR appear unrelated to neuropathy or symptomatic neuropathy, cumulative levodopa usage, or serum vitamin B(12) levels in patients with PD. The occurrence of LMR may relate to the earlier onset of PD, raising the possibility of common pathophysiological mechanisms for PD and RLS, of which LMR may be an early manifestation in some patients.
不宁腿综合征（RLS）在帕金森病（PD）中的患病率已得到广泛研究，但研究结果存在矛盾。最近，人们发现 PD 患者的周围神经病变和腿部运动不安（LMR）比对照组更为常见。
我们的目的是确定 RLS 或 LMR 是否可能继发于周围神经病变，或继发于其目前推测的决定因素，即累积左旋多巴的使用和维生素 B（12）代谢，在 PD 患者中。
我们比较了 37 例 PD 患者和 37 例年龄和性别匹配的对照组中 RLS、LMR 和周围神经病变的患病率。确定了 RLS/LMR 与周围神经病变和症状性周围神经病变、累积左旋多巴使用和维生素 B（12）水平之间的相关性。
PD 患者和对照组的 RLS 患病率相当（16.2%比 10.8%；P = 0.30）。PD 患者的 LMR 明显比对照组更为常见（40.5%比 16.2%；P = 0.038），周围神经病变也是如此（37.8%比 8.1%；P = 0.005）。在 PD 患者中，无论是 RLS 还是 LMR，均与周围神经病变或症状性周围神经病变、累积左旋多巴暴露或血清维生素 B（12）水平无关。LMR 与 PD 发病年龄较早呈显著正相关趋势（P = 0.069）。
RLS 和 LMR 似乎与 PD 患者的周围神经病变或症状性周围神经病变、累积左旋多巴使用或血清维生素 B（12）水平无关。LMR 的发生可能与 PD 的发病年龄较早有关，这表明 PD 和 RLS 可能存在共同的病理生理机制，而 LMR 可能是某些患者的早期表现。
