Huang Yi-Xian, Zhang Qi-Lin, Huang Cai-Li, Wu Wen-Qi, Sun Jia-Wei
Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Front Neurol. 2021 Oct 26;12:734570. doi: 10.3389/fneur.2021.734570. eCollection 2021.
To objective of the study was to investigate whether serum brain-derived neurotrophic factor (BDNF) levels are associated with the severity of restless legs syndrome (RLS) in Parkinson's disease (PD). A total of 249 PD patients with ( = 53) and without RLS ( = 196) and 326 age-matched controls were included in this study. All the serum BDNF levels of the participants were measured. The International Restless Legs Syndrome Study Group Rating Scale (IRLSSG-RS) was administered for the severity of RLS. The severity of PD patients were assessed by the Unified PD Rating Scale (UPDRS) and the Hoehn and Yahr (H-Y) stage. The prevalence of RLS was significantly higher in PD patients (21.3%) than in the controls group (7.4%) ( < 0.05). The IRLSSG-RS score in PD patients with RLS (16.25 ± 5.24) was significantly increased than in controls with RLS (12.08 ± 3.99) ( < 0.01). The serum BDNF levels were significantly decreased in PD patients with RLS than in PD patients without RLS, controls without RLS, and controls with RLS ( < 0.001). BDNF levels were negatively associated with IRLSSG-RS in both PD patients with RLS and controls with RLS group (both < 0.01). Multiple regression analysis confirmed that in either PD with RLS or controls with RLS group, BDNF was an independent contributor to IRLSSG-RS (both < 0.01). Decreased serum BDNF levels may be involved in the pathophysiology of RLS in PD, suggesting that it may serve as a potential blood biomarker of diagnostic value for RLS in PD.
本研究的目的是调查血清脑源性神经营养因子（BDNF）水平是否与帕金森病（PD）患者不安腿综合征（RLS）的严重程度相关。本研究纳入了总共249例患有（n = 53）和未患有RLS（n = 196）的PD患者以及326名年龄匹配的对照。测量了所有参与者的血清BDNF水平。采用国际不安腿综合征研究组评分量表（IRLSSG-RS）评估RLS的严重程度。通过统一PD评定量表（UPDRS）和Hoehn及Yahr（H-Y）分期评估PD患者病情的严重程度。PD患者中RLS的患病率（21.3%）显著高于对照组（7.4%）（P < 0.05）。患有RLS的PD患者的IRLSSG-RS评分（16.25±5.24）显著高于患有RLS的对照组（1十二点零八±3.99）（P < 0.01）。患有RLS的PD患者的血清BDNF水平显著低于未患有RLS的PD患者、未患有RLS的对照组以及患有RLS的对照组（P < 0.001）。在患有RLS的PD患者组和患有RLS的对照组中，BDNF水平均与IRLSSG-RS呈负相关（均P < 0.01）。多元回归分析证实，在患有RLS的PD组或患有RLS的对照组中，BDNF都是IRLSSG-RS的独立影响因素（均P < 0.0）。血清BDNF水平降低可能参与了PD中RLS的病理生理过程，这表明它可能作为PD中RLS具有诊断价值的潜在血液生物标志物。
