Greenwood B, Targett G
Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel St., London WC 1E 7HT, UK.
Parasite Immunol. 2009 Sep;31(9):582-6. doi: 10.1111/j.1365-3024.2009.01140.x.
An unexpectedly large reduction in the burden of malaria has recently been achieved in a number of malaria endemic countries following the scaling up of effective treatment and simple vector control programmes. These achievements question the need for a partially effective malaria vaccine targeted at disease prevention. If an anti-disease vaccine is to replace or supplement existing control measures a high level of efficacy, sustained over a number of years, will be required. Recent successes in malaria control have re-awakened interest in the possibility of malaria elimination in areas where this was not previously considered to be a feasible objective. Malaria vaccines with transmission-blocking properties could play a key role in future elimination programmes.
近期，一些疟疾流行国家在扩大有效治疗和简单病媒控制项目规模后，疟疾负担意外大幅减轻。这些成果让人质疑是否需要一种预防疾病效果有限的疟疾疫苗。如果一种抗疾病疫苗要替代或补充现有的控制措施，就需要具备数年持续的高效能。疟疾控制方面的近期成功重新唤起了人们对在以前认为不可行的地区消除疟疾可能性的兴趣。具有阻断传播特性的疟疾疫苗可能在未来的消除计划中发挥关键作用。
