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一种类似Rns的调控基因，用于控制定居因子抗原I（CFA/I）菌毛蛋白的表达。 该基因调控定居因子抗原I（CFA/I）的表达。

A rns-like regulatory gene for colonization factor antigen I (CFA/I) that controls expression of CFA/I pilin.

作者信息

Caron J, Scott J R

机构信息

Department of Microbiology and Immunology, Emory University Health Sciences Center, Atlanta, Georgia 30322.

出版信息

Infect Immun. 1990 Apr;58(4):874-8. doi: 10.1128/iai.58.4.874-878.1990.

DOI:10.1128/iai.58.4.874-878.1990
PMID:1969396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC258554/
Abstract

Colonization factor antigens (CFA) are needed for adherence of human enterotoxigenic Escherichia coli (ETEC) strains to their hosts. The CFA/II antigens, CS1 and CS2, which are found in some ETEC strains, require the plasmid-encoded gene rns for expression (J. Caron, L. M. Coffield, and J. R. Scott, Proc. Natl. Acad. Sci. USA 86:963-967, 1989). Other ETEC strains express CFA/I, whose synthesis and assembly require genes on two unlinked regions (regions 1 and 2) of a plasmid (G. A. Willshaw, H. R. Smith, and B. Rowe, FEMS Microbiol. Lett. 16:101-106, 1983). We report that CFA/I region 2 DNA can substitute for rns to cause expression of CS1 and CS2. The cfaR gene in region 2 is defined by a mutation abolishing both expression of CFA/I and complementation of a rns mutant for expression of CS1 or CS2. In a strain containing only region 1, complementation for expression of CFA/I by a plasmid containing rns+ is inefficient but is adequate to cause hemagglutination by the CFA/I adhesin.

摘要

定居因子抗原（CFA）是人类产肠毒素大肠杆菌（ETEC）菌株黏附于宿主所必需的。在一些ETEC菌株中发现的CFA/II抗原，即CS1和CS2，其表达需要质粒编码的基因rns（J. 卡隆、L. M. 科菲尔德和J. R. 斯科特，《美国国家科学院院刊》86:963 - 967, 1989年）。其他ETEC菌株表达CFA/I，其合成和组装需要质粒上两个不连锁区域（区域1和区域2）的基因（G. A. 威尔肖、H. R. 史密斯和B. 罗，《FEMS微生物学快报》16:101 - 106, 1983年）。我们报道CFA/I区域2的DNA可以替代rns来促使CS1和CS2的表达。区域2中的cfaR基因由一个突变定义，该突变既消除了CFA/I的表达，也消除了rns突变体中CS1或CS2表达的互补作用。在仅含有区域1的菌株中，含有rns⁺的质粒对CFA/I表达的互补作用效率低下，但足以使CFA/I黏附素引起血细胞凝集。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/258554/e7caa35ec18c/iai00052-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/258554/fd2e9d6c8fa3/iai00052-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/258554/e7caa35ec18c/iai00052-0040-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/258554/fd2e9d6c8fa3/iai00052-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a0b3/258554/e7caa35ec18c/iai00052-0040-b.jpg

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