Black R E, Brown K H, Becker S, Alim A R, Huq I
Am J Epidemiol. 1982 Mar;115(3):315-24. doi: 10.1093/oxfordjournals.aje.a113308.
Longitudinal studies were done in two villages rural Bangladesh to learn more about the interactions between infectious diseases and the nutritional status of children. Diarrheal diseases, identified by surveillance of 197 children aged 2-60 months, were studied for bacterial, viral and parasitic enteropathogens in 1978-1979. The annual incidence of diarrhea was highest in children aged 2-11 months, and declined progressively with age from seven to four episodes per child per year. An enteropathogen was identified from rectal cultures taken during diarrhea in 51% of episodes and from 6% of monthly cultures taken when diarrhea was not present. Enterotoxigenic Escherichia coli were the pathogens found most frequently, followed by shigellae and rotaviruses. Diarrheal episodes associated with shigellae had the longest duration, while episodes associated with Vibrio cholerae or with rotavirus were more frequently associated with dehydration. E. coli diarrhea had a peak incidence during the hot months, and shigellosis was more frequent during the cool, dry months.
在孟加拉国农村的两个村庄开展了纵向研究，以进一步了解传染病与儿童营养状况之间的相互作用。1978 - 1979年，通过对197名年龄在2至60个月的儿童进行监测，确定了腹泻病，并对其进行细菌、病毒和寄生虫肠道病原体研究。腹泻的年发病率在2至11个月大的儿童中最高，随后随年龄增长而逐渐下降，从每年每名儿童七次腹泻降至四次。在51%的腹泻发作期间采集的直肠培养物中以及在无腹泻时采集的每月培养物的6%中鉴定出了一种肠道病原体。产肠毒素大肠杆菌是最常发现的病原体，其次是志贺氏菌和轮状病毒。与志贺氏菌相关的腹泻发作持续时间最长，而与霍乱弧菌或轮状病毒相关的发作更常伴有脱水。大肠杆菌性腹泻在炎热月份发病率最高，志贺氏菌病在凉爽干燥的月份更为常见。
