回首2009年，如今距离抗病毒疗法诞生已过去50年，从历史角度进行审视。

Looking back in 2009 at the dawning of antiviral therapy now 50 years ago an historical perspective.

作者信息

De Clercq Erik

机构信息

Rega Institute for Medical Research, Department of Microbiology and Immunology, K.U.Leuven, Leuven, Belgium.

出版信息

Adv Virus Res. 2009;73:1-53. doi: 10.1016/S0065-3527(09)73001-5.

DOI:10.1016/S0065-3527(09)73001-5

PMID:19695380

Abstract

In 1959, 5-iodo-2'-deoxyuridine (IDU) was described, the first antiviral drug ever to be (and still) marketed (for the topical treatment of herpetic keratitis). Now 50 years following the description (of the synthesis) of IDU, we have 50 compounds on the market that have been licensed for clinical use in the treatment of virus infections. Of those 50, exactly 25 have been formally approved as anti-HIV drugs; the other 25 have been formally approved for the treatment of other virus infections: herpes simplex virus (HSV), varicella-zoster virus (VZV), cytomegalovirus (CMV), hepatitis B virus (HBV), hepatitis C virus (HCV), and influenza virus infections.

摘要

1959年，5-碘-2'-脱氧尿苷（IDU）被发现，它是有史以来（至今仍是）上市的第一种抗病毒药物（用于局部治疗疱疹性角膜炎）。如今，在IDU（合成方法）被描述50年后，我们有50种已获许可用于临床治疗病毒感染的化合物上市。在这50种药物中，有25种已被正式批准为抗HIV药物；另外25种已被正式批准用于治疗其他病毒感染：单纯疱疹病毒（HSV）、水痘-带状疱疹病毒（VZV）、巨细胞病毒（CMV）、乙型肝炎病毒（HBV）、丙型肝炎病毒（HCV）和流感病毒感染。